基本信息
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Bio
The Joyce lab studies how chromosomes are functionally organized and folded in 3-D space and time. Our primary goal is to understand how the structure and position of chromosomes within the nucleus is established and inherited across cell divisions, and how dysfunctional organization contributes to genome instability. To this end, we develop and utilize technologies to visualize chromosomes and subchromosomal regions at single-cell resolution and in a high-throughput fashion. Our research takes advantage of both Drosophila and mammalian systems as models for chromosome function, which allows us to directly address the conservation and health relatedness of the mechanisms we discover.
Current Projects:
1. Spatial organization of the epigenome
2. Regulatory logic underlying condensin-mediated chromatin folding
3. High-throughput screening for novel pathways important for genome organization
4. Impact of aging on 3D organization
Current Projects:
1. Spatial organization of the epigenome
2. Regulatory logic underlying condensin-mediated chromatin folding
3. High-throughput screening for novel pathways important for genome organization
4. Impact of aging on 3D organization
Research Interests
Papers共 72 篇Author StatisticsCo-AuthorSimilar Experts
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Noor M Kotb, Gulay Ulukaya,Ankita Chavan,Son C Nguyen, Lydia Proskauer,Eric F Joyce,Dan Hasson,Madhav Jagannathan,Prashanth Rangan
Genes & developmentno. 9-10 (2024): 436-454
Yiman Liu,Qinglan Li,Lele Song,Chujie Gong, Sylvia Tang,Krista A Budinich,Ashley Vanderbeck, Kaeli M Mathias,Gerald B Wertheim,Son C Nguyen,Riley Outen,Eric F Joyce,
Thomas Malachowski,Keerthivasan Raanin Chandradoss, Ravi Boya,Linda Zhou, Ashley L. Luppino,Chuanbin Su,Kenneth Pham,Spencer A. Haws,Ji Hun Kim,Han-Seul Ryu,Chunmin Ge,Jennifer M. Luppino,
Ankita Chavan,Randi Isenhart,Son C Nguyen,Noor Kotb,Jailynn Harke, Anna Sintsova, Gulay Ulukaya,Federico Uliana,Caroline Ashiono,Ulrike Kutay,Gianluca Pegoraro,Prashanth Rangan,
bioRxiv : the preprint server for biologyno. 9-10 (2023): 415-435
Natureno. 7972 (2023): 209-217
Parisha P. Shah,Kathleen C. Keough, Ketrin Gjoni,Garrett T. Santini,Richard J. Abdill,Nadeera M. Wickramasinghe,Carolyn E. Dundes,Ashley Karnay,Angela Chen, Rachel E.A. Salomon, Patrick J. Walsh, Son C. Nguyen,
bioRxiv : the preprint server for biology (2023)
Li-Hsin Chang,Sourav Ghosh,Andrea Papale,Jennifer M. Luppino, Mélanie Miranda,Vincent Piras,Jéril Degrouard,Joanne Edouard,Mallory Poncelet, Nathan Lecouvreur,Sébastien Bloyer,Amélie Leforestier,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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