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职业迁徙
个人简介
My interests lie in clinical and translational research in advanced prostate cancer, including trial design, and development of novel agents. I piloted the early trials targeting the androgen receptor in advanced prostate cancer, developing ketoconazole and contributing to an understanding of its mechanisms of activity and resistance. I subsequently was centrally involved with the development of two novel androgen signaling inhibitors, abiraterone acetate and apalutamide, from first in human studies to FDA approval.
I have also been involved in the early application of immunotherapy to prostate cancer, developing sipuleucel T from first in human studies through FDA approval, and undertaking the first in human testing of ipilimumab, the first immune check point inhibitor to be clinically developed.
Understanding the mechanisms of resistance in advanced prostate cancer has been a research focus. I was principal investigator of a $10 million multi-center Stand Up to Cancer (SU2C)/Prostate Cancer Foundation Dream Team Award undertaking deep genomic characterization of prostate cancer metastases, in order to elucidate patterns of resistance in abiraterone and/or enzalutamide treated patients. Important observations from this, and subsequent work have included unexpectedly high prevalence rates of treatment associated small cell/neuroendocrine prostate cancer (t-SCNC), as well key structural variants which contribute to progression of castration-resistant disease, observed in the largest Whole Genome Sequencing series to date of metastatic advanced prostate cancer specimens.
研究兴趣
论文共 592 篇作者统计合作学者相似作者
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Hewitt Chang, Jaqueline Marquez,Brandon K. Chen,Daniel M. Kim, Michael L. Cheng,Eric V. Liu,Hai Yang,Li Zhang,Meenal Sinha,Alexander Cheung,Serena S. Kwek,Eric D. Chow,
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European Urologyno. 6 (2024): 511-516
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David Alan Quigley,Julian C. Hong, Nicholas Lillis,Ali Sabbagh, Isabel D Friesner, Adina Bailey,Rahul Raj Aggarwal,Li Zhang,Meera Reddy Chappidi, Hari Singhal, Joel Greshock,Ke Zhang,
Journal of Clinical Oncologyno. 4_suppl (2024): 192-192
JU open plusno. 4 (2024)
Aishwarya Subramanian, Meng Zhang, Marina Sharifi, Thaidy Moreno-Rodriguez, Eric Feng, Nicholas R Rydzewski, Raunak Shrestha, Xiaolin Zhu, Shuang G Zhao, Rahul Aggarwal,Eric J Small, Chien-Kuang Cornelia Ding,
bioRxiv : the preprint server for biology (2024)
JU open plusno. 4 (2024)
Cancer Researchno. 7_Supplement (2024)
Journal of Clinical Oncologyno. 16_suppl (2024)
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