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个人简介
Elisabete Ferreiro is currently an assistant researcher at the Center for Neuroscience and Cell Biology, University of Coimbra, integrated in the group MitoXT - Mitochondrial Toxicology and Experimental Therapeutics, headed by Dr.Paulo Oliveira. Her main expertise area is in neuroscience and cell biology. Currently, she is interested in developing new therapeutic strategies and create personalized medicine platforms for Amyotrophic lateral sclerosis (ALS). In more detail, she is conducting research to develop an innovative personalized medicine platform for ALS, based on human neuronal cell differentiated from urine-derived stem cells isolated from ALS patients' urine and test several drugs as potential therapeutic treatment of this disease.
She graduated in Biology from the University of Coimbra (UC), in 2002, and completed her PhD degree in Biology, also from UC, in 2008. Her PhD works, supervised by Prof. Claudia Fragão Pereira (Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra) led to the thesis 'Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by amyloid-beta and prion peptides. Implications for the etiopathogenesis of Alzheimer’s disease and Prion disorders'. During her PhD works, E. Ferreiro demonstrated the existence of endoplasmic reticulum (ER) stress as a major contribution for cell death induced by the amyloid beta (Abeta) peptide and PrP106–126, in both Alzheimer’s disease and Prion disorders. Besides, she further showed the relevance of the communication between the ER and the mitochondria for apopotic pathway. In 2008, E. Ferreiro started her post-doc research studies focused on identifying mechanisms involved in Alzheimer's disease (AD) and explore hippocampal adult neurogenesis along with signalling pathways with potential to improve upon it. In 2013, she initiated a second postdoctoral program in the group of Dr Ana Cristina Rego (Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra). During this period Elisabete Ferreiro studied the mitochondrial control of NMDA receptor-dependent calcium rise evoked by amyloid-ß 1-42 oligomers in rat cortical neurons and also evaluated whether hyperglycemia enhances Alzheimer´'s disease pathology by perturbing adult hippocampal neurogenesis. .
In 2015, E Ferreiro joined the COST action BM1402, and was an active member and establishing several collaborations and short-term exchanges. In 2017 she spent 6 months at the Achucarro Basque Center (Spain), where she extended her knowledge on hippocampal neurogenesis, stem cells and consolidate her collaborations with experts in the field.
As a result of her research activity, she has published 38 scientific papers in international peer reviewed journals, with over 2650 citations, an h index of 26 an i10 index of 29 and an accumulated impact factor of 164.333.
研究兴趣
论文共 60 篇作者统计合作学者相似作者
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EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
Cellsno. 13 (2023): 1763-1763
Carla Cavaleiro,Goncalo J. M. Afonso, Paulo J. Oliveira,Jorge Valero,Sandra I. Mota,Elisabete Ferreiro
FRONTIERS IN MOLECULAR NEUROSCIENCE (2023): 1229728-1229728
Clinical Journal of Mycology Vol VI Edition 1. (2022)
D. Mena,P. Soares,F. Cagide,S. Benfeito,L. Grilo,D. F. Silva, P. Valente, P. Pinheiro,E. Ferreiro,J. Teixeira,F. Silva,F. Borges,
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Molecular Neurobiologyno. 10 (2022): 6373-6396
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作者统计
#Papers: 60
#Citation: 2765
H-Index: 28
G-Index: 52
Sociability: 5
Diversity: 1
Activity: 1
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