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Genetics and genome sequencing have supplied an extensive parts list for how to create an embryo, yet it is still impossible to construct a precise description of the process from genome-scale data. Existing models of signaling pathways have too many parameters to fit experimentally, and they ignore the complexities of cell biology. Siggia’s group recently developed mathematical descriptions for embryonic patterning that encapsulate how a field of cells can react to an external signal and choose between three discrete fates. The resulting mathematics is geometric and naturally meshes with the phenomenological concepts from the pre-molecular era of embryology.
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Archishman Raju,Eric D Siggia
Development (Cambridge, England) (2024)
Development, growth & differentiationno. 5 (2023): 245-254
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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biorxiv(2023)
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Cell stem cellno. 6 (2022): 962-972.e4
Cell Reports Methodsno. 9 (2022): 100297
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