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Bacterial cell wall synthesis
The bacterial cell wall synthesis pathway is the most accessible essential pathway of bacteria and hence a very important target for antibiotic development. The pathway starts in the cytosol with the synthesis of two UDP-activated precursors UDP-GlcNAc and UDP-MurNAc-pentapeptide (see figure). This is followed by the assembly of the complete peptidoglycan subunit on a polyisoprenoid carrier, undecaprenyl phosphate, resulting in a product called Lipid II, the ultimate peptidoglycan precursor. Lipid II is then transported to the exterior side of the plasma membrane and used by bi-functional penicillin binding proteins (PBPs) for the synthesis of the cell wall. The resulting undecaprenyl pyrophosphate is then recycled back to the cytosol, de-phosphorylated after which it is ready to be used again. Our research mainly focuses on the membrane events of this cycle and the different projects are outlined below.
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论文共 198 篇作者统计合作学者相似作者
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Biochimica et biophysica acta. Molecular and cell biology of lipidsno. 4 (2024): 159467-159467
JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 7 (2024): 4421-4432
Shehrazade Jekhmane,Maik G N Derks,Sourav Maity,Cornelis J Slingerland, Kamaleddin H M E Tehrani,João Medeiros-Silva, Vicky Charitou, Danique Ammerlaan,Céline Fetz, Naomi A Consoli,Rachel V K Cochrane, Eilidh J Matheson,
Nature microbiologypp.1-14, (2024)
Biochimica et Biophysica Acta (BBA) - Biomembranesno. 3 (2024): 184282-184282
Journal of Structural Biology: X (2024): 100101-100101
CELLno. 19 (2023): 4059-4073.e27
Biochimica et biophysica acta. Biomembranesno. 6 (2023): 184160
Biophysical journalno. 23 (2023): 4503-4517
European Journal of Medicinal Chemistry (2023): 115853-115853
New Developments in NMR NMR Spectroscopy for Probing Functional Dynamics at Biological Interfacespp.563-582, (2022)
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