基本信息
浏览量:116
职业迁徙
个人简介
Dr. Pan investigates the molecular mechanisms of growth control and tissue homeostasis. He is best known for pioneering work on the Hippo signaling pathway, an evolutionarily conserved developmental pathway that controls organ size in all animals. Using Drosophila as a model, his laboratory made a series of discoveries that defined, in a stepwise manner, the key molecular events in the Hippo signaling pathway. His team further established a critical role for the Hippo pathway in controlling mammalian organ size, regeneration and tumorigenesis. Besides research on the Hippo pathway, the Pan laboratory also elucidated the molecular function of the Tsc1 and Tsc2 tumor suppressor genes, linking Tsc1/Tsc2 to Rheb and TOR signaling. This work provided the key molecular insight for the use of mTOR inhibitors in the treatment of Tuberous Sclerosis. His current efforts are aimed at understanding the composition, mechanism and regulation of the Hippo pathway, elucidating its physiological roles in normal development and diseases, and discovery of chemical probes targeting the Hippo pathway.
研究兴趣
论文共 167 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Trends in Biochemical Sciences (2024)
Yinan Yang, Huijing Zhou, Xiawei Huang, Chengfang Wu, Kewei Zheng, Jingrong Deng,Yonggang Zheng, Jiahui Wang, Xiaofeng Chi, Xianjue Ma, Huimin Pan, Rui Shen,
Nature communicationsno. 1 (2024): 145-145
crossref(2023)
crossref(2023)
crossref(2023)
crossref(2023)
Yue Lu, Tezin Walji,Benjamin Ravaux,Pratima Pandey,Bing Li, Kevin H Lam,Ruihui Zhang,David J Goldhamer,Rong Li,David W Schmidtke,Duojia Pan,Elizabeth H Chen
biorxiv(2023)
引用0浏览0引用
0
0
Yu Ting Ong,Jorge Andrade, Max Armbruster,Chenyue Shi, Marco Castro,Ana S. H. Costa,Toshiya Sugino,Guy Eelen,Barbara Zimmermann,Kerstin Wilhelm, Joseph Lim,Shuichi Watanabe,
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn