基本信息
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Bio
I have started my scientific career in 1992 with leukocyte surface mapping using monoclonal antibodies as diagnostic tools.
Over the time, my interest is now focused to the fields oncology and host-pathogen interactions. Being trained as an immunologist, I work on the immune recognition of cancer stem cells and infectious pathogens with respect to their highly mutated surface phenotype, which is instrumental for the effective interaction with the other cells during the microevolutionary battle in the human body.
My mission is to validate already known biomarkers of the contact interface between highly plastic invaders and the dynamic defense forces of our immune system. The toolbox consists of multiparametric single cell analysis (flow cytometry, microscopy and sequencing) strengthened by development of next-generation binding reagents. These are better versions of current monoclonal antibodies based on comparative structural analysis, rational design of display libraries followed by in vitro evolution and selection systems - altogether mimicking the natural processes in a much faster fashion.
Currently, large dataset visualization using clustering and embedding tools - their development and application - becomes part of my scientific endeavor.
Research Interests
Papers共 59 篇Author StatisticsCo-AuthorSimilar Experts
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P. Vohradska,M. Kripnerova,K. Houfkova,H. S. Parmar,J. Kuncova,M. Hora,O. Hes, M. Rajtmajerova,K. Drbal,M. Pesta,I. Subrt,J. Hatina
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Jiri Hatina,Michaela Kripnerova, Nikita Khazov, Martha Sardeli Krimpeni,Karel Drbal,Siegfried Schwarz
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#Papers: 62
#Citation: 2243
H-Index: 21
G-Index: 47
Sociability: 6
Diversity: 0
Activity: 0
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