Our laboratory has a longstanding interest in lipid autacoid mediators (also called eicosanoids) and their pathophysiologic roles in cancer biology. While exploring the mechanism by which PPAR pathways control tumor growth, we became interested in the cytochrome P450-derived arachidonic acid products called epoxyeicosatrienoic acids (EETs). These eicosanoids are down-regulated following PPAR activation. We recently demonstrated the endothelium and certain stromal cells secrete EETs, and that these lipid autacoids stimulate multi-organ metastasis and escape from tumor dormancy. Furthermore, we have found that EETs play a critical role in both normal processes [such as wound healing and organ regeneration] and disease processes. We also collaborate closely with Professor Charles Serhan (Brigham & Women’s Hospital), to study the role endogenous anti-inflammatory lipid autacoids such as the omega-3 fatty acid-derived resolvins and their role in inflammation resolution. In addition, we also collaborate with industry (e.g. Inception Sciences, San Diego) to study eicosanoid modulating drugs in experimental cancer models.