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Our lab is interested in the regulation of pre-mRNA splicing and the biochemical mechanisms that control changes in splice sites. The sequences of metazoan genomes, with their relatively low gene numbers, have highlighted the question of how protein number can be expanded beyond the gene number for a complex organism. Alternative splicing, which allows the production of multiple mRNAs and hence multiple proteins from a single gene, is a major contributor to protein diversity. However, despite its key role in gene expression, this process is poorly understood mechanistically.
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论文共 20 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
Jennifer M. Achiro,Yang Tao,Fuying Gao,Chia-Ho Lin, Marika Watanabe, Sylvia Neumann,Giovanni Coppola,Douglas L. Black,Kelsey C. Martin
FRONTIERS IN MOLECULAR NEUROSCIENCE (2024): 1334862-1334862
Mohammad Nazim,Chia-Ho Lin,An-Chieh Feng, Wen Xiao,Kyu-Hyeon Yeom, Mulin Li, Allison E. Daly, Xianglong Tan,Ha Vu,Jason Ernst,Michael F. Carey,Stephen T. Smale,
Cell Stem Cellno. 5 (2024): 754-771.e6
Proceedings of the National Academy of Sciences of the United States of Americano. 47 (2018): E11061-E11070
Celine K. Vuong, Weizheng Wei,Ji-Ann Lee,Chia-Ho Lin, Andrey Damianov,Luis de la Torre-Ubieta, Reem Halabi, Klara Olofsdotter Otis,Kelsey C. Martin, Thomas J. O’Dell,Douglas L. Black
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