基本信息
浏览量:17
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Research Interests
My laboratory uses budding yeast to study fundamental processes in cell biology. Our approach has been to develop novel genetic reagents and cell biological methods to analyze these complex processes in vivo, coupled with the development and exploitation of in vitro assays to reveal underlying molecular mechanisms. Together these approaches have allowed us to make significant contributions to following three areas of research.
Higher Order Chromosome Structure is important for the integrity, transmission and expression of chromosomes. The molecular bases for the formation, maintenance and disassembly of higher order chromosome organization are major unsolved problems in cell biology.
The Maintenance of Genome Integrity (chromosome number and integrity) is critical to prevent cell inviability, inherited disorders and disease. A major threat to genome integrity is breaks in the DNA that can be misrepaired to cause gross chromosomal rearrangements (GCR) such as translocations, internal deletions or terminal truncations. While the cause of DSBs and their repair have been studied intensively, major new discoveries will be required to explain the massive rearrangement of chromosomes associated with cancer.
Stress Tolerance is fundametnal to an organisms ability to survive internal and environmental perturbations. We study stress response through the lens of desiccation tolerance, a remarkable trait found in rare species in all kingdoms of life. Desiccation tolerance has significant biomedical potential and will likely provide novel insights into the role of different cell biological pro
My laboratory uses budding yeast to study fundamental processes in cell biology. Our approach has been to develop novel genetic reagents and cell biological methods to analyze these complex processes in vivo, coupled with the development and exploitation of in vitro assays to reveal underlying molecular mechanisms. Together these approaches have allowed us to make significant contributions to following three areas of research.
Higher Order Chromosome Structure is important for the integrity, transmission and expression of chromosomes. The molecular bases for the formation, maintenance and disassembly of higher order chromosome organization are major unsolved problems in cell biology.
The Maintenance of Genome Integrity (chromosome number and integrity) is critical to prevent cell inviability, inherited disorders and disease. A major threat to genome integrity is breaks in the DNA that can be misrepaired to cause gross chromosomal rearrangements (GCR) such as translocations, internal deletions or terminal truncations. While the cause of DSBs and their repair have been studied intensively, major new discoveries will be required to explain the massive rearrangement of chromosomes associated with cancer.
Stress Tolerance is fundametnal to an organisms ability to survive internal and environmental perturbations. We study stress response through the lens of desiccation tolerance, a remarkable trait found in rare species in all kingdoms of life. Desiccation tolerance has significant biomedical potential and will likely provide novel insights into the role of different cell biological pro
研究兴趣
论文共 97 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
crossref(2020)
加载更多
作者统计
#Papers: 97
#Citation: 14470
H-Index: 58
G-Index: 80
Sociability: 5
Diversity: 3
Activity: 4
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn