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My laboratory has been interested in the regulation of cancer cells by insulin and the insulin-like growth factors (IGFs). Our laboratory was one of the first to show a role for this pathway in Ewing’s sarcoma and breast cancer. The laboratory remains focused on the signaling pathways regulated by the IGFs that are relevant to cancer biology. We have shown that IGF signaling is dependent on activation of specific adaptor proteins and downstream signaling molecules. Our lab is also evaluating the role for the fetal isoform of the insulin receptor (IR-A) in breast cancer biology. Interactions between estrogen receptor expressing breast cancers and insulin/IGFs result in enhanced growth and increased survival. While some anti-IGF strategies have been tested in clinical trials, toxicities and lack of targeting of IR-A has limited the clinical efficacy and the laboratory is working on strategies to target IR-A specifically without inhibition of the adult isoform of insulin receptor (IR-B).
Research Interests
Papers共 549 篇Author StatisticsCo-AuthorSimilar Experts
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Michael Carpenter,Nuri Temiz, Mahmoud Ibrahim,Matthew Jarvis, Margaret Brown,Prokopios Argyris,William Brown,Douglas Yee,Reuben Harris
Cancer Researchno. 9_Supplement (2024): PO5-27
CANCER RESEARCHno. 3 (2024)
crossref(2024)
Cancer Researchno. 6_Supplement (2024): 1207-1207
Cardio-Oncologyno. 1 (2024): 1-6
Journal of Clinical Oncologyno. 16_suppl (2024)
Clinical cancer research : an official journal of the American Association for Cancer Researchno. 4 (2024): 729-740
Kingsley V. Chow, Silver Al Khafaji,Denise Wolf,Christina Yau, Kailey Dubinsky, Elene Tsopurashvili, Kirthiga Ramalingam, Fluorentine van Nouhuijs, Zheyun Xun, Anna van Montfort,Diane Heditsian,Douglas Yee,
Cancer Researchno. 6_Supplement (2024): 6804-6804
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Author Statistics
#Papers: 566
#Citation: 26235
H-Index: 82
G-Index: 155
Sociability: 8
Diversity: 0
Activity: 4
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