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In general, my lab has been studying the neuroimmunological and neuroendocrine basis of integrated biology and physiology. In terms of pathophysiology, we have incorporated a list of models that addressed metabolic disorders (obesity and diabetes), cardiovascular disorders (hypertension), and aging disorders, and are expanding our interests to include some infectious diseases, brain cancers and additional neuroimmune problems. Among our various approaches, one highlight is related to neural stem cells, in particular hypothalamic neural stem cells (htNSC) that my lab initially identified. For example, we have been studying the neuroendocrine functions of htNSC in regulating physiological homeostasis, while how loss of these functions could lead to various conditions of systemic disorders. Overall, my lab research has led to several new paradigms and concepts, notably including hypothalamic microinflammation, hypothalamic control of aging, existence of htNSC, and identification of NSC-released miRNA/piRNA exosomes. In line with these topics, my lab research is an integral part of many related research communities on campus, such as Institute of Neuroimmunology and Inflammation, Diabetes Research Center, Institute for Aging Research, Stem Cell Institute, and Cancer Center. In this background, my lab is continuing to develop new interdisciplinary models, strategies, and approaches to address fundamental questions in these areas and to generate technologies for improving health.
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Life Metabolism (2022)
Nature Agingno. 10 (2021): 904-918
NATURE AGINGno. 11 (2021): 1068-1068
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