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Research Interests
The general interest of our laboratory is nucleic acid transactions, specifically, the mechanisms used to mobilize transposable DNA elements (a process called transposition) and how RNA binding proteins control patterns of alternative pre-mRNA splicing. About half the human genome is composed of transposons; transposable DNA insertions have been linked to human disease gene mutations and chromosomal rearrangements and are thought to be important for genome and organismal evolution. Our research focuses on the P element family of transposable elements found in the fruit fly, Drosophila melanogaster and more recently the vertebrate homologs of the P element transposase, THAP9. P element transposition is related to retroviral DNA integration, such as HIV, and to the process by which immunoglobulin and T-cell receptor genes are rearranged in the vertebrate immune system [V(D)J recombination]. The P element system offers the ability to effectively combine the use of biochemical, genetic, molecular biological and proteomic approaches to study fundamental aspects of transposition mechanisms. A second research area of research involves how patterns of alternative splicing of pre-mRNA are set up in a cell-type and tissue-specific manner, which is an important mechanism for the regulation of gene expression, evolution of organismal complexity in metazoans and leads to significant proteomic diversification. Understanding how pre-mRNA splicing is controlled will be important since at least 40% of the known human and mouse disease gene mutations affect the splicing process. Our studies deal with the interaction of proteins with RNA and DNA as well as the assembly, composition, structure, function and biochemical activities of these complex nucleoprotein machines.
The general interest of our laboratory is nucleic acid transactions, specifically, the mechanisms used to mobilize transposable DNA elements (a process called transposition) and how RNA binding proteins control patterns of alternative pre-mRNA splicing. About half the human genome is composed of transposons; transposable DNA insertions have been linked to human disease gene mutations and chromosomal rearrangements and are thought to be important for genome and organismal evolution. Our research focuses on the P element family of transposable elements found in the fruit fly, Drosophila melanogaster and more recently the vertebrate homologs of the P element transposase, THAP9. P element transposition is related to retroviral DNA integration, such as HIV, and to the process by which immunoglobulin and T-cell receptor genes are rearranged in the vertebrate immune system [V(D)J recombination]. The P element system offers the ability to effectively combine the use of biochemical, genetic, molecular biological and proteomic approaches to study fundamental aspects of transposition mechanisms. A second research area of research involves how patterns of alternative splicing of pre-mRNA are set up in a cell-type and tissue-specific manner, which is an important mechanism for the regulation of gene expression, evolution of organismal complexity in metazoans and leads to significant proteomic diversification. Understanding how pre-mRNA splicing is controlled will be important since at least 40% of the known human and mouse disease gene mutations affect the splicing process. Our studies deal with the interaction of proteins with RNA and DNA as well as the assembly, composition, structure, function and biochemical activities of these complex nucleoprotein machines.
研究兴趣
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Oriol Busquets,Hanqin Li,Khaja Mohieddin Syed,Pilar Alvarez Jerez,Jesse Dunnack, Riana Lo Bu,Yogendra Verma,Gabriella R. Pangilinan, Annika Martin, Jannes Straub, YuXin Du, Vivien M. Simon,
bioRxiv the preprint server for biology (2024)
biorxiv(2024)
Genes & developmentno. 1-2 (2024): 11-30
bioRxiv the preprint server for biology (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2022)
semanticscholar(2022)
Hanqin Li,Oriol Busquets,Yogendra Verma,Khaja Mohieddin Syed, Nitzan Kutnowski, Gabriella R Pangilinan,Luke A Gilbert,Helen S Bateup,Donald C Rio,Dirk Hockemeyer,Frank Soldner
crossref(2022)
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