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职业迁徙
个人简介
AREAS OF RESEARCH INTEREST
Chemical Biology, Chemical Neurosciences, Natural Product Chemistry, Chemical Synthesis
Neuroscience is one of the most exciting areas of research and synthetic chemistry can contribute much to its further development. Our current focus lies on the functional manipulation of ion channels and GPCRs using synthetic photoswitches, usually azobenzenes. The artificial photoreceptors so obtained can be inserted into neurons and other cell types and can be used to control various biological pathways with light (Photopharmacology). One of our major biological goals is the restoration of vision in the blind using synthetic photoswitches. The reach of photopharmacology, however, goes well beyond applications in neuroscience and sensory physiology. It is already clear that this approach is particular useful to controlling the highly dynamic systems that underlie cell motility, cell division and (unwanted) proliferation. As such, photopharmacology provides powerful tools for cell biology and could open a new direction in targeted cancer chemotherapy.
Chemical Biology, Chemical Neurosciences, Natural Product Chemistry, Chemical Synthesis
Neuroscience is one of the most exciting areas of research and synthetic chemistry can contribute much to its further development. Our current focus lies on the functional manipulation of ion channels and GPCRs using synthetic photoswitches, usually azobenzenes. The artificial photoreceptors so obtained can be inserted into neurons and other cell types and can be used to control various biological pathways with light (Photopharmacology). One of our major biological goals is the restoration of vision in the blind using synthetic photoswitches. The reach of photopharmacology, however, goes well beyond applications in neuroscience and sensory physiology. It is already clear that this approach is particular useful to controlling the highly dynamic systems that underlie cell motility, cell division and (unwanted) proliferation. As such, photopharmacology provides powerful tools for cell biology and could open a new direction in targeted cancer chemotherapy.
研究兴趣
论文共 912 篇作者统计合作学者相似作者
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Johannes Morstein, Alexander Amatuni,Anton Shuster,Wolfgang Kuttenlochner, Tongil Ko,Daniel Abegg,Michael Groll,Alexander Adibekian,Hans Renata,Dirk H. Trauner
ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONno. 8 (2024): e202314791-e202314791
Chikako Nakajima,Masato Sawada, Erika Umeda, Yuma Takagi, Norihiko Nakashima,Kazuya Kuboyama,Naoko Kaneko, Satoaki Yamamoto, Haruno Nakamura,Naoki Shimada,Koichiro Nakamura,Kumiko Matsuno,
Nature Communicationsno. 1 (2024): 1-19
Nynke A. Veprek,Madeline H. Cooper,Laura Laprell,Emily Jie-Ning Yang, Sander Folkerts, Ruiyang Bao,Malgorzata Boczkowska, Nicholas J. Palmer,Roberto Dominguez,Thomas G. Oertner,Liza A. Pon,J. Bradley Zuchero,
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2024)
Martin Barkey,Rebecca Büchner, Alwin Wester,Stefanie D Pritzl,Maksim Makarenko,Qizhou Wang,Thomas Weber,Dirk Trauner,Stefan A Maier,Andrea Fratalocchi, Theobald Lohmüller,Andreas Tittl
Lina S. Schneider,Karin von Schwarzenberg,Thorsten Lehr,Melanie Ulrich, Rebekka Kubisch-Dohmen, Johanna Liebl,Dirk Trauner,Dirk Menche,Angelika M. Vollmar
crossref(2023)
crossref(2023)
biorxiv(2023)
Lina S. Schneider,Karin von Schwarzenberg,Thorsten Lehr,Melanie Ulrich, Rebekka Kubisch-Dohmen, Johanna Liebl,Dirk Trauner,Dirk Menche,Angelika M. Vollmar
crossref(2023)
crossref(2023)
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