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While it is apparent that eukaryotic gene activation occurs in the context of chromatin, the precise nature of "chromatin structure" associated with gene activation and silencing is not clear. A variety of measurable characteristics of a gene locus, such as covalent histone modifications, DNA methylation and the timing of DNA replication have been shown to correlate with transcriptional activity and are presumed to regulate gene expression. Our research is aimed at further understanding, at the level of individual gene loci and genome-wide, how these nuclear events influence the expression phenotype in higher eukaryotes and how they are propagated during cell division.
While it is apparent that eukaryotic gene activation occurs in the context of chromatin, the precise nature of "chromatin structure" associated with gene activation and silencing is not clear. A variety of measurable characteristics of a gene locus, such as covalent histone modifications, DNA methylation and the timing of DNA replication have been shown to correlate with transcriptional activity and are presumed to regulate gene expression. Our research is aimed at further understanding, at the level of individual gene loci and genome-wide, how these nuclear events influence the expression phenotype in higher eukaryotes and how they are propagated during cell division.
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Papers共 172 篇Author StatisticsCo-AuthorSimilar Experts
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Giulio Superti-Furga,Marta Agostinho, Jo Bury, Simon Cook, Christine Durinx, Anita Ender,Henri van Luenen,Anders H. Lund,Rene H. Medema,Marta Miaczynska,Dorthe Nickel,Pier Giuseppe Pelicci,
Sevi Durdu,Murat Iskar,Luke Isbel,Leslie Hoerner, Christiane Wirbelauer, Lukas Burger,Daniel Hess,Vytautas Iesmantavicius,Dirk Schubeler
biorxiv(2024)
NATURE GENETICSno. 6 (2024): 1203-1212
Inês A. M. Barbosa, Rajaraman Gopalakrishnan, Samuele Mercan,Thanos P. Mourikis,Typhaine Martin,Simon Wengert,Caibin Sheng, Fei Ji,Rui Lopes,Judith Knehr,Marc Altorfer,Alicia Lindeman,
Alicia K Michael, Lisa Stoos,Priya Crosby,Nikolas Eggers,Xinyu Y Nie,Kristina Makasheva,Martina Minnich, Kelly L Healy,Joscha Weiss,Georg Kempf,Simone Cavadini,Lukas Kater,
Natureno. 7969 (2023): 385-393
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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#Papers: 170
#Citation: 26257
H-Index: 80
G-Index: 162
Sociability: 7
Diversity: 0
Activity: 1
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