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RESEARCH AND INTERESTS
We are exploiting unique physics, microenvironment control, and the potential for automation associated with miniaturized systems for applications in basic biology, medical diagnostics, and cellular engineering. Current research is focused on:
(i) Quantitative cell biology and mechanics of cancer metastasis. Microfluidic methods to control the surface chemistry, mechanical, and soluble environment are well suited to address questions associated with cell migration and movement. We are particularly interested in the process of cancer metastasis and intravasation.
(ii) Nonlinear microfluidics. Nonlinear fluid dynamic effects are usually not considered in microfluidic systems but may provide simple methods to manipulate and sort rare populations of cells at high-throughputs. We are studying the physical basis of inertial migration of particles and engineering novel portable and robust diagnostic and analysis systems using this phenomenon for applications in the developed and developing world.
(iii) Microfluidic directed cellular evolution. Microfluidic technologies may offer advantages in creating new useful selection criteria for cellular evolution. Besides gaining an understanding of dominant molecular pathways in controlling these behaviors, the resultant evolved cell populations and genetic modifications may be useful for therapeutic applications.
We are exploiting unique physics, microenvironment control, and the potential for automation associated with miniaturized systems for applications in basic biology, medical diagnostics, and cellular engineering. Current research is focused on:
(i) Quantitative cell biology and mechanics of cancer metastasis. Microfluidic methods to control the surface chemistry, mechanical, and soluble environment are well suited to address questions associated with cell migration and movement. We are particularly interested in the process of cancer metastasis and intravasation.
(ii) Nonlinear microfluidics. Nonlinear fluid dynamic effects are usually not considered in microfluidic systems but may provide simple methods to manipulate and sort rare populations of cells at high-throughputs. We are studying the physical basis of inertial migration of particles and engineering novel portable and robust diagnostic and analysis systems using this phenomenon for applications in the developed and developing world.
(iii) Microfluidic directed cellular evolution. Microfluidic technologies may offer advantages in creating new useful selection criteria for cellular evolution. Besides gaining an understanding of dominant molecular pathways in controlling these behaviors, the resultant evolved cell populations and genetic modifications may be useful for therapeutic applications.
研究兴趣
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Gyeo-Re Han, Artem Goncharov,Merve Eryilmaz,Hyou-Arm Joung,Rajesh Ghosh, Geon Yim, Nicole Chang, Minsoo Kim, Kevin Ngo, Marcell Veszpremi, Kun Liao,Omai B. Garner,
arxiv(2024)
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Rajesh Ghosh, Alyssa Arnheim,Mark van Zee, Lily Shang, Citradewi Soemardy, Rui-Chian Tang,Michael Mellody,Sevana Baghdasarian, Edwin Sanchez Ochoa, Shun Ye,Siyu Chen,Cayden Williamson,
Analytical chemistry (2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 14 (2024): e2320442121-e2320442121
Walker Peterson, Joshua Arenson, Soichiro Hata, Laura Kacenauskaite, Tsubasa Kobayashi, Takuya Otsuka, Hanqing Wang,Yayoi Wada,Kotaro Hiramatsu, Zhikai He,Jean-Emmanuel Clement, Chenqi Zhang,
crossref(2024)
Tianlong Zhang,Dino Di Carlo, Chwee Teck Lim, Tianyuan Zhou, Guizhong Tian,Tao Tang, Amy Q. Shen,Weihua Li,Ming Li, Yang Yang,Keisuke Goda, Ruopeng Yan,
JOURNAL OF INVESTIGATIVE DERMATOLOGYno. 9 (2023): B33-B33
biorxiv(2023)
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