基本信息
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Bio
Major Scientific Contributions
Dr. Thanos has made pioneering and seminal contributions in the elucidation of the mechanisms by which human genes are turned on and off in response to environmental stimuli and during development and cellular differentiation. More specifically:
He discovered the existence of enhanceosomes, i.e. the higher order three-dimensional structures composed of control DNA elements present in enhancer regions and transcription factor conglomerates. He elucidated the mechanisms of enhanceosome function in activation of gene transcription and provided for the first time a nearly complete molecular picture of the “translation” of the enhancer DNA code to specific chromatin dynamic modifications involved in the control of transcription initiation.
He discovered the existence of the architectural transcription factors, which function by promoting the assembly of enhanceosomes and not by activating/repressing transcription directly.
He provided for the first time a nearly complete molecular picture of how the enhancer DNA code is interpreted by transcription factors and chromatin modifying complexes to control gene expression.
An additional notable and more recent accomplishment is the identification of a novel molecular mechanism involving interchromosmal interactions underlined gene expression stochasticity in genetically identical cell populations of the immune system.
Research Interests
Papers共 173 篇Author StatisticsCo-AuthorSimilar Experts
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ANNALS OF THE RHEUMATIC DISEASESno. 3 (2024): 342-350
Pavlos Pantelis,George Theocharous,Nefeli Lagopati,Dimitris Veroutis,Dimitris-Foivos Thanos, Giasemi-Panagiota Lampoglou,Natassa Pippa,Maria-Anna Gatou,Ioanna Tremi,Angelos Papaspyropoulos,Efthymios Kyrodimos,Evangelia A Pavlatou,
Journal of Experimental & Clinical Cancer Researchno. 1 (2023): 1-20
PloS oneno. 7 (2023): e0288005-e0288005
Communications biologyno. 1 (2023): 752-16
D Veroutis,OD Argyropoulou,AV Goules,K Kambas,DA Palamidas,K Evangelou,S Havaki,A Polyzou, E Xingi, E Karatza,K Boki,A Cavazza,
Annals of the Rheumatic Diseases (2023)
Yiannis Drosos,Eumorphia G. Konstantakou, Aggeliki-Stefania Bassogianni, Konstantinos-Stylianos Nikolakopoulos, Dimitra G. Koumoundourou,Sophia P. Markaki,Ourania E. Tsitsilonis,Gerassimos E. Voutsinas,Dimitrios Valakos,Ema Anastasiadou,Dimitris Thanos,Athanassios D. Velentzas,
CANCERSno. 14 (2023): 3730-3730
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