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Due to my retirement in 2005 the Institute for Cell Biochemistry and Clinical Neurobiology at the University Medical Center Hamburg-Eppendorf (UKE) was closed down. The help of the directorate of the Center for Molecular Neurobiology Hamburg (ZMNH) by providing space for the continuation of my scientific activities is greatly acknowledged. Most of the ongoing research was carried out in collaboration with my former co-workers Stefan Kindler and Hans-Jürgen Kreienkamp, now group leaders at the Institute for Human Genetics, UKE. Research has been focused on how nerve cells manage to respond to external and internal signals in order to maintain and regulate their cellular architecture. As shown earlier signal transduction processes involving neurotransmitter receptors are mediated by a series of defined protein-protein interactions. We have identified specific interacting proteins for the C-terminal, intracellular regions of each subtype of G-protein coupled somatostatin receptors (SSTR1-5). Some interacting partners, such as the PDZ domain protein PIST, have a function in membrane targeting of SSTR3 and SSTR5. Others such as the tight junction protein MUPP1 or the postsynaptic scaffold proteins PSD-95 (interacting with SSTR4) or SSTRIP/shank (interacting with SSTR2) link the receptors to large signaling complexes, such as the postsynaptic density (PSD) in excitatory synapses of the central nervous system.
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