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Research in our lab is broadly directed towards the elucidation of the fundamental nature of gas-phase ions and their chemical and physical interactions with molecules in the gas phase with an eye to possible applications in analytical mass spectrometry and other related areas. The approach is largely experimental, relying primarily on a powerful and versatile Selected-Ion Flow Tube (SIFT) tandem mass spectrometer: a tandem quadrupole mass spectrometer in which the two quadrupoles are separated by a helium flow reactor operating at ca. 0.35 Torr. The SIFT can be fitted to an Inductively-Coupled Plasma (ICP), an almost universal source for atomic metal cations, or an electrospray ionization (ESI) source that allows the injection of measurable amounts of singly and multiply charged positive and negative ions generated in solution (e.g. multiply protonated proteins and peptides). Also, the single quadrupole detector of the SIFT has been replaced with a triple quadrupole (QqQ) mass spectrometer and this has provided increased mass range (up to m/z 2000), increased sensitivity, and a means to perform low-pressure CID experiments for ion bond-energy and ion-structure determinations (a vast improvement over our previous multi-collision CID operation). Exploratory studies of electrospray ion production and dissociation are performed with two commercial ESI/QqQ instruments. Both the ICP/SIFT/QqQ and the ESI/SIFT/QqQ facilities can provide specific reaction rates and product distributions for selected ion/molecule reactions from kinetic measurements, as well as energetic and structural information on individual ions from collision-induced dissociation (CID) experiments.
Research Interests
Papers共 511 篇Author StatisticsCo-AuthorSimilar Experts
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ISRAEL JOURNAL OF CHEMISTRYno. 7-8 (2023)
MASS SPECTROMETRY REVIEWS (2023)
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Author Statistics
#Papers: 514
#Citation: 18174
H-Index: 63
G-Index: 105
Sociability: 6
Diversity: 3
Activity: 22
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