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We study gene regulation by steroid hormones, focusing on transcriptional mechanisms, hormone-dependent cancers, and sex-biased gene action. Steroid receptors are ligand-activated transcription factors with diverse functions, yet several act via a common DNA binding site and use common coregulators. We examine how specific regulation is attained by the androgen receptor (AR).
To study the central role of AR in prostate cancer and to model human disease, we converted the mouse gene to the human sequence (humanized AR mice). Variant hAR alleles in mice confer differences in cancer initiation, progression, and response to therapy. This allowed us to study treatment resistance, particularly by somatic AR mutations. In both mouse and human tumors, AR variants use diverse mechanisms to evade therapy. In collaborative studies, variant ARs also impact brain development and behaviors.
To study the central role of AR in prostate cancer and to model human disease, we converted the mouse gene to the human sequence (humanized AR mice). Variant hAR alleles in mice confer differences in cancer initiation, progression, and response to therapy. This allowed us to study treatment resistance, particularly by somatic AR mutations. In both mouse and human tumors, AR variants use diverse mechanisms to evade therapy. In collaborative studies, variant ARs also impact brain development and behaviors.
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论文共 111 篇作者统计合作学者相似作者
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Mara P. Steinkamp,Orla A. O'Mahony,Michele Brogley,Haniya Rehman,Elizabeth W. LaPensee,Saravana Dhanasekaran,Matthias D. Hofer,Rainer Kuefer, Arul Chinnaiyan, Mark A. Rubin, Kenneth J. Pienta,Diane M. Robins
crossref(2023)
Mara P. Steinkamp, Orla A. O'Mahony, Michele Brogley, Haniya Rehman, Elizabeth W. LaPensee,Saravana Dhanasekaran,Matthias D. Hofer,Rainer Kuefer, Arul Chinnaiyan, Mark A. Rubin, Kenneth J. Pienta,Diane M. Robins
crossref(2023)
Mara P. Steinkamp, Orla A. O'Mahony, Michele Brogley, Haniya Rehman, Elizabeth W. LaPensee,Saravana Dhanasekaran,Matthias D. Hofer,Rainer Kuefer, Arul Chinnaiyan, Mark A. Rubin, Kenneth J. Pienta,Diane M. Robins
crossref(2023)
Mara P. Steinkamp,Orla A. O'Mahony,Michele Brogley,Haniya Rehman,Elizabeth W. LaPensee,Saravana Dhanasekaran,Matthias D. Hofer,Rainer Kuefer, Arul Chinnaiyan, Mark A. Rubin, Kenneth J. Pienta,Diane M. Robins
crossref(2023)
NeuroImage (2021): 117594
Elyza Kelly,Fantao Meng,Hirofumi Fujita,Felipe Morgado, Yasaman Kazemi,Laura C Rice,Chongyu Ren,Christine Ochoa Escamilla,Jennifer M Gibson, Sanaz Sajadi,Robert J Pendry, Tommy Tan,
Samir R. Nath, Matthew L. Lieberman,Zhigang Yu,Caterina Marchioretti,Samuel T. Jones,Emily C. E. Danby, Kate M. Van Pelt,Gianni Sorarù,Diane M. Robins,Gillian P. Bates,Maria Pennuto,Andrew P. Lieberman
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