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I have a degree in Chemistry from the Universidad Distrital "Francisco José de Caldas" and a Master's in Biology with an emphasis in Computational and Structural Molecular Biochemistry and Bioinformatics from the Pontificia Universidad Javeriana, and Ph.D. in Sciences - Biology at the National University of Colombia, with the Doctoral Thesis "Reconstruction, Modeling and Simulation of the Metabolic Network and Quorum-Sensing, involved in the Regulation of a Specific Phenotype in Pseudomonas aeruginosa."
I have experience in research work and acquired great skill and expertise in experimental work in extracting and purifying brain proteins, specifically with NMDA-activated glutamate ionotropic receptors and other neuropeptides such as NPY and CGRP. In addition, I have training and experience in theoretical work in Bioinformatics, in which I did my master's thesis. In that research, I worked on designing an algorithm for the in silico signal peptide prediction using iGluR-NMDA as a model and the prediction of some post-translational modifications, such as glycosylation sites.
Later, I worked on the electronic basis of the Receptor-Ligand interaction, with which I started to study the matter from ab-inition models modeling these interactions at the quantum level with programs like Gamess and Spartan to determine important characteristics of the ligands-agonists and Antagonists of the receptors that were used as models (ionotropic receptors of glutamate activated by NMDA and Dopamine receptors).
Since 2009, I have been researching Systems Biology, specifically in the in silico reconstruction, modeling, and simulation of biological networks as dynamical systems under the Flux Balance Analysis (FBA) approach. Therefore, my interest is focused on the proposal and execution of research projects that involve the reconstruction of biological networks: gene regulation, metabolic, and cell signaling, which are mathematically and computationally modeled as deterministic systems and dynamical systems, allowing a better understanding of the behavior of complex biological systems. Currently, I am working on projects involving 1) the reconstruction and modeling of gene regulatory networks focused on finding candidate genes for genomic instability as a cancer marker. 2) Analysis of comparative genomics between Homo sapiens and Arabidopsis thalina to find candidate genes to be new cancer markers. 3) Analysis of Protein-Protein interaction networks of plant species such as Oryza sativa and Arabidopsis thaliana and 4) Genome-scale reconstruction and modeling of the metabolic network of Oryza sativa to study changes in the metabolic phenotype caused by biotic and abiotic stress.
Research Interests
Papers共 13 篇Author StatisticsCo-AuthorSimilar Experts
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Metabolitesno. 5 (2023): 659-659
Diana Carolina Clavijo-Buriticá,Chrystian C. Sosa, Rafael Cárdenas Heredia,Arlen James Mosquera, Andrés Álvarez,Jan Medina,Mauricio Quimbaya
Heliyonno. 4 (2023): e15367-e15367
SSRN Electronic Journal (2022)
SSRN Electronic Journalno. 1 (2022): 110528-110528
Andres Felipe Cuspoca, Laura Lorena Diaz, Alvaro Fernando Acosta, Marcela Katherine Penaloza,Yardany Rafael Mendez,Diana Carolina Clavijo,Juvenal Yosa Reyes
Queer Epistemologies in Educationpp.217-239, (2020)
Diana Carolina Clavijo Buriticá, Bárbara Valeria Mejía, Lina María Rojas, Leandro Sáenz,Juvenal Yosa
Revista Cuarzono. 2 (2018): 7-15
Diana Carolina Clavijo Buriticá, Bárbara Valeria Mejía Bohórquez, Lina María Rojas, Hector Leandro Sáenz Castro
Revista Cuarzono. 1 (2018): 7-16
Diana Carolina Clavijo B.,Juvenal Yosa R.,Orlando Acevedo S., Claudia Cifuentes, Carlos M Estévez Bretón
Revista Cuarzono. 2 (2017): 73-79
B Diana Carolina Clavijo,R Juvenal Yosa,S Orlando Acevedo, Claudia Cifuentes, Carlos M Estévez Bretón
Revista Cuarzono. 2 (2017): 73-79
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Author Statistics
#Papers: 15
#Citation: 31
H-Index: 2
G-Index: 5
Sociability: 4
Diversity: 0
Activity: 0
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