基本信息
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Career Trajectory
Bio
I have several years of experience in the areas of Molecular biology, Cancer Biology, Virology, cytokine-induced innate immunity, Signal transduction, autophagy, and transcriptional regulation of gene expression. My seminal contributions include the discovery of GRIMs, a novel group of tumor suppressor genes; novel cytokine inducible gene regulatory elements, their cognate transcription factors and signal transduction pathways that control them. I am also one of the first few investigators who described mechanisms of viral resistance to Interferon actions. I have developed the concept of GRIMs and identified the critical genes involved in this process. My lab was the first to describe GRIM-19, a novel tumor suppressor, monoclonal antibodies against it, its interacting proteins, functionally inactivating somatic mutations, loss of expression in primary human tumors. We have also developed conditional knockout mouse models that allow the study of tumor suppressors and oncogenes. We were also one of first group to apply genome-wide expression knockdown technologies before the description of whole genome sequences and RNAi technology.
Research Interests
Papers共 222 篇Author StatisticsCo-AuthorSimilar Experts
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期刊级别
合作者
合作机构
CYTOKINE (2024): 156544-156544
Mei Yang,Libo Xu,Xiaodong Wei,Jiaying Yang,Ding Wang,Jixuan Liu, Shuxin Shi,Xuyang Chen,Mengxin Li,Yingtong Wang, Qian Luo, Yong Tian,
crossref(2024)
Journal of cell scienceno. 10 (2024)
Phytomedicine : international journal of phytotherapy and phytopharmacology (2024): 155199-155199
Yang Xing,Feroza Yasinjan, Shuhao Sun,Jiaying Yang, Yajie Du,Haotian Zhang, Yueyang Liang,Huayue Geng,Yingtong Wang,Jicheng Sun, Zihang Yu,Dhan V. Kalvakolanu,
Nano Today (2024): 102386
Current cancer drug targets (2024)
BIOCHEMISTRY AND CELL BIOLOGYno. 4 (2023): 361-376
crossref(2023)
Ling Zhang,Lifang Gao, Lijuan Zhao,Baofeng Guo,Kun Ji, Yong Tian,Jinguo Wang,Hao Yu,Jiadi Hu,Dhananjaya V. Kalvakolanu,Dennis J. Kopecko,Xuejian Zhao,
crossref(2023)
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Author Statistics
#Papers: 204
#Citation: 7370
H-Index: 50
G-Index: 78
Sociability: 6
Diversity: 0
Activity: 1
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