基本信息
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Bio
Our laboratory has 3 primary research goals. The FIRST goal is to understand how glioblastoma (GBM) cell indoleamine 2,3 dioxygenase 1 (IDO; IDO1) increases immunosuppressive T-reg infiltration, suppresses the immune response, and decreases overall survival in mouse models and human subjects with glioblastoma. Our previous work discovered that glioblastoma cell IDO1 non-enzymically upregulates immunosuppressive complement factor H (CFH) and factor H-like 1 (FHL-1) in human GBM cells, which in-turn, suppresses the anti-tumor immune response through intratumoral T-reg and MDSC accumulation.
Research Interests
Papers共 196 篇Author StatisticsCo-AuthorSimilar Experts
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Brain, Behavior, & Immunity - Health (2024): 100753-100753
Siqi Chen,Jie Fan,Ping Xie,Jihae Ahn, Michelle Fernandez,Leah K Billingham,Jason Miska, Jennifer D Wu,Derek A Wainwright,Deyu Fang, Jeffrey A Sosman,Yong Wan,
The Journal of clinical investigationno. 8 (2024)
Nature Communicationsno. 1 (2024): 1-20
Amna Siddiqui, Dylan Ross, Ronak Jani,Vikram Prabhu,Shelly Lo,Derek Wainwright,Stasia Rouse,Jigisha Thakkar
Maria Elisa Caetano-Silva,Akriti Shrestha,Audrey F. Duff,Danica Kontic,Patricia C. Brewster, Mikaela C. Kasperek,Chia-Hao Lin,Derek A. Wainwright,Diego Hernandez-Saavedra, Jeffrey A. Woods,Michael T. Bailey,Thomas W. Buford,
biorxiv(2024)
Akriti Shrestha, Mikaela Kasperek, Maria Elisa Caetano-Silva,Derek Wainwright, Robert McCuscker,Jacob Allen
Prashant Bommi, Paige Monsen, Kristen Lauing,Lijie Zhai, Kevin Barton, Ewa Borys,Douglas Anderson,Vikram Prabhu,Jigisha Thakkar,Rimas Lukas, Gary Schiltz,Derek Wainwright
Neuro-Oncologyno. Supplement_5 (2023)
Neuro-oncologyno. Supplement_5 (2023): v147-v148
Amna Siddiqui, Dylan Ross, Ronak H Jani,Vikram C Prabhu,Shelly Lo,Derek A Wainwright,Stasia Rouse,Tamer Refaat, Yirong Zhu,Jigisha P Thakkar
crossref(2023)
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