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A long-term goal of my laboratory is to understand how the exo-endocytic cycle is spatially regulated during cellular morphogenesis. Two major focuses are the spatial-temporal regulation of membrane traffic in adipocytes in response to insulin signaling and in fibroblasts during cell migration. To elucidated mechanisms that regulate membrane trafficking, my laboratory uses advanced imaging and analysis coupled with RNAi knockdown of key regulator machinery (e.g. exocyst complex). Innovative live cell TIRFM and spinning-disk confocal imaging at the 'CINEMA' imaging center are used to visualize directly, at the single-vesicle level, where and how membrane traffic is delivered and regulated. As impaired vesicle exocytosis is associated with type 2 diabetes and abnormal cell motility is associated with metastasis and cancer, the knowledge gained with this research will be highly significant in understanding the pathologies of these diseases.
Research Interests
Papers共 183 篇Author StatisticsCo-AuthorSimilar Experts
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Cellno. 7 (2024): 1769-1784.e18
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Heng Zhang,Jianhang Wang,Luhong Jin, Yunqi Zhu,Yuting Guo,Meng Zhang,Yuhui Zhang, Zhixiong Wang, Yisun Su,Yicong Wu,Baohua Ji,Derek Toomre,
bioRxiv : the preprint server for biology (2023)
Emerging infectious diseasesno. 8 (2023): 1711-1713
Kohei Kume,Jaewoong Lee, Zhangliang Cheng,Mark E. Robinson,Etienne Leveille,Kadriye Nehir Cosgun,Lai N. Chan,Yanzhi Feng, David Fonseca, Dhruv Khanduja,Derek Toomre, Markus Muschen
BLOOD (2023)
Nature cardiovascular researchno. 12 (2022): 1116-1118
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2022)
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