基本信息
浏览量:7
职业迁徙
个人简介
She has served on the Advisory Councils of the American Cancer Society, the National Institutes of General Medical Sciences, the American Society for Cell Biology, and the Gordon Research Conferences. She served as the 2020 President of the Genetics Society of America and serves on the Board of Scientific Counselors of the National Cancer Institute. She is an elected Fellow of the American Society for Cell Biology, the American Association for the Advancement of Science and was elected to the National Academy of Sciences in 2021.
Every day, every single one of the trillions of cells in the human body makes an active decision whether to live or die. These decisions are important. When the wrong cells live, we suffer from cancer or autoimmune disease. When too many or the wrong cells die, we suffer from degenerative diseases and the dire consequences of heart attack and stroke. Denise Montell’s lab has reported a surprising reversibility of the cell suicide process known as apoptosis. Cells that have progressed beyond steps previously considered to be points of no return can reverse the dying process, recover, and go on to proliferate. This has both positive and negative consequences. We are testing the hypothesis that the ability of cells to return from the brink of death – which we have named anastasis (Greek: “rising to life”) - serves to salvage cells that are difficult to replace such as heart muscle cells or neurons in the adult brain. Therefore discovering how to enhance anastasis holds the potential to lead to revolutionary new therapies for heart and neurodegenerative diseases. On the other hand, this survival mechanism may allow tumor cells to escape chemotherapy. Therefore discovering how to inhibit anastasis could enhance the effectiveness of current cancer therapies. Currently we are investigating the molecular mechanisms that trigger and execute this cell survival process and we have developed a biosensor so we can identify and follow cells that have undergone anastasis in living animals.
The general theme is the lab is to identify under-appreciated cell behaviors and tease apart the underlying molecular mechanisms as well as the physiological significance. A second major interest of the lab focuses on cell motility. Without cell migrations embryos could not develop, wounds would not heal and the nervous and immune systems could neither form nor function. But cell movements have a dark side, and the ability to move also contributes to tumor metastasis, which is a major cause of death for cancer patients. Denise Montell’lab has developed a new in vivo model for the study of cell motility and employs a powerful combination of molecular genetics, live imaging and photo-manipulation techniques to decipher the molecular mechanisms that determine when, where and how cells move. Other examples of understudied cell behavior under investigation in the lab include cell cannibalism, extension of stem cell lifespan during diapause, and neolamination.
研究兴趣
论文共 175 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
biorxiv(2024)
Cancer Researchno. 6_Supplement (2024): 6002-6002
Xiaoran Guo, Morgan Mutch,Alba Yurani Torres,Maddalena Nano, Nishi Rauth, Jacob Harwood, Drew McDonald,Zijing Chen,Craig Montell,Wei Dai,Denise J. Montell
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024): 1-2
Seminars in Cell & Developmental Biology (2024): 1-2
crossref(2023)
The Journal of cell biologyno. 11 (2023)
crossref(2023)
crossref(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn