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The emergence and spread of various multidrug-resistant bacterial strains have posed alarming challenges to public health and agriculture worldwide. Public demand for new antibiotics is enormous, yet drug development pipelines of the pharmaceutical industry started to run dry with limited targets available for inventing new bactericidal antibiotics. It is important to uncover potential therapeutic targets. Our group has been working on virulence regulation in the human pathogen Pseudomonas aeruginosa and plant pathogen Pseudomonas syringae, which are of world-wide importance. These pathogens rely on quorum sensing systems and type III secretion system to invade their hosts, which is finely regulated by a group of transcription factors and signalling pathways. Research in our group has led to the identification of a variety of new virulence-associated two-component systems, transcription factors and their molecular mechanisms. We have mapped the transcription factor-based regulatory networks for both superbugs. Tuning their expression and developing inhibitors are key for the development of strategies to control Pseudomonas infections. Our work also demonstrates that RNA modifications exist in a wide-range of bacterial species, which suggests their potential important roles in gene regulation.
The emergence and spread of various multidrug-resistant bacterial strains have posed alarming challenges to public health and agriculture worldwide. Public demand for new antibiotics is enormous, yet drug development pipelines of the pharmaceutical industry started to run dry with limited targets available for inventing new bactericidal antibiotics. It is important to uncover potential therapeutic targets. Our group has been working on virulence regulation in the human pathogen Pseudomonas aeruginosa and plant pathogen Pseudomonas syringae, which are of world-wide importance. These pathogens rely on quorum sensing systems and type III secretion system to invade their hosts, which is finely regulated by a group of transcription factors and signalling pathways. Research in our group has led to the identification of a variety of new virulence-associated two-component systems, transcription factors and their molecular mechanisms. We have mapped the transcription factor-based regulatory networks for both superbugs. Tuning their expression and developing inhibitors are key for the development of strategies to control Pseudomonas infections. Our work also demonstrates that RNA modifications exist in a wide-range of bacterial species, which suggests their potential important roles in gene regulation.
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Mingsen Li,Huizhen Guo,Bofeng Wang, Zhuo Han,Siqi Wu,Jiafeng Liu,Huaxing Huang,Jin Zhu,Fengjiao An, Zesong Lin,Kunlun Mo,Jieying Tan,
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HELIYONno. 1 (2024): e24029-e24029
Chinese Chemical Letterspp.110044, (2024)
Kun Li,Chancan Liao, Tingting Wang,Liyang Song,Xin Deng,Wei Yan,Rongxiang Fang,Yantao Jia,Xiaoyan Tang
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