Dr. Albanes conducts a molecular epidemiologic program that is focused on prostate and other cancers in relation to micronutrients (particularly vitamins D, E, and A), vitamin supplementation, and metabolite profiles through biochemical, genetic, and mechanistic investigations. His recent prospective metabolomics studies have discovered novel serologic profiles for prostate cancer, glioma, and vitamin supplementation and serum status. Dr. Albanes has also highlighted the importance of hyperinsulinemia, a hyperthyroid state, higher vitamin D and A status, and lower vitamin E status in elevated prostate cancer risk. This high-incidence malignancy is of essentially unknown etiology other than being more frequent in men with a first-degree family history of the disease, in African-Americans, and being associated with over 100 common genetic variants.