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职业迁徙
个人简介
The ultimate goal of our laboratory is to discover mechanisms to promote healthy ageing and alleviate age-related diseases. We aim to understand the molecular basis of ageing by focusing on a pathological adaptation to ageing, namely protein aggregation. We and others have identified several hundred proteins that accumulate in aberrant clumps both inside and outside of cells in ageing organisms in the absence of disease processes.
Mainly, we work with Caenorhabditis elegans, a transparent nematode about 1 mm in length, which is an outstanding model for ageing research. Ageing is easily monitored in this simple organism which undergoes rapid ageing over the course of two weeks. Our research in C. elegans reveals that protein aggregates contribute to the decline in muscle function with age. Therefore, identifying ways to keep proteins in their correct shape will likely promote healthy ageing.
Recently, we developed a C. elegans model to study extracellular protein aggregation. Using this model, we are exploring new ways to maintain the quality of proteins outside the cell. Other important goals of the lab are to understand what makes certain tissues more vulnerable to protein aggregation and how to enhance stress resistance with age. Mechanisms and concepts identified in C. elegans could open up new avenues in the search for therapies to delay disabilities of ageing in humans.
Mainly, we work with Caenorhabditis elegans, a transparent nematode about 1 mm in length, which is an outstanding model for ageing research. Ageing is easily monitored in this simple organism which undergoes rapid ageing over the course of two weeks. Our research in C. elegans reveals that protein aggregates contribute to the decline in muscle function with age. Therefore, identifying ways to keep proteins in their correct shape will likely promote healthy ageing.
Recently, we developed a C. elegans model to study extracellular protein aggregation. Using this model, we are exploring new ways to maintain the quality of proteins outside the cell. Other important goals of the lab are to understand what makes certain tissues more vulnerable to protein aggregation and how to enhance stress resistance with age. Mechanisms and concepts identified in C. elegans could open up new avenues in the search for therapies to delay disabilities of ageing in humans.
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论文共 36 篇作者统计合作学者相似作者
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Hiroyuki Uechi,Sindhuja Sridharan,Jik Nijssen, Jessica Bilstein,Juan M. Iglesias-Artola, Satoshi Kishigami, Virginia Casablancas-Antras,Ina Poser, Eduardo J. Martinez,Edgar Boczek, Michael Wagner,Nadine Tomschke,
biorxiv(2024)
Raimund Jung, Marie C Lechler,Ana Fernandez-Villegas,Chyi Wei Chung, Harry C Jones, Yoon Hee Choi, Maximilian A Thompson,Christian Rödelsperger,Waltraud Röseler,Gabriele S Kaminski Schierle,Ralf J Sommer,Della C David
user-5d8054e8530c708f9920ccce(2020)
Ivan Gallotta, Aneet Sandhu,Maximilian Peters,Martin Haslbeck,Raimund Jung, Sinem Agilkaya, Jane L. Blersch,Christian Rödelsperger,Waltraud Röseler, Chaolie Huang,Ralf J. Sommer,Della C. David
Chaolie Huang,Sara Wagner-Valladolid,Amberley D Stephens,Raimund Jung,Chetan Poudel,Tessa Sinnige, Marie C Lechler,Nicole Schlörit,Meng Lu,Romain F Laine,Claire H Michel,Michele Vendruscolo,
eLife (2019)
Chaolie Huang,Sara Wagner-Valladolid,Amberley D. Stephens,Raimund Jung,Chetan Poudel,Tessa Sinnige, Marie C. Lechler,Nicole Schlörit,Romain F. Laine,Claire H. Michel,Michele M Vendruscolo,Clemens F. Kaminski,
Marie C Lechler,Emily D Crawford, Nicole Groh, Katja Widmaier,Raimund Jung,Janine Kirstein,Jonathan C Trinidad,Alma L Burlingame,Della C David
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