基本信息
views: 23
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
A. Personal Statement
Understanding the biophysical properties of individual neurons and how they process information is fundamental to understanding the brain. Thus, new or improved tools to facilitate these studies are critical. Because the principal function of a neuron is to process electrical signals, one tool that is of particular significance is high-speed, high spatial resolution membrane potential imaging (Vm imaging). I have been using optical measurements of electrical activity from individual neurons since beginning my postdoctoral fellowship with Lawrence Cohen in 1983. My laboratory recently reported a dramatic improvement (based on laser technology) in the sensitivity of voltage imaging by a factor of approximately 50 which allowed the recording of voltage transients from individual dendritic spines (Holthoff et al., 2010; Popovic et al., 2012) as well as from the axonal arbor (Foust et al., 2010; 2011; Popovic et al., 2011). The aim of this long-term effort was to provide a way to directly investigate the relationship between membrane potential signals and basic molecular mechanisms that underlie both excitatory and inhibitory synaptic transmission and plasticity at the level of individual synapses on dendritic spines. Understanding fundamental mechanisms that govern signal integration at the level of dendritic spines is an absolute requirement which naturally leads to the most effective treatments of pathological changes.
B. Positions and Honors
Positions and Employment
1971-75 Research Assistant, Dept. Cryobiology and Bioenergetics, Inst. Biol. Res. Belgrade, Yugoslavia.
1971-75 Teaching Assistant, International Brain Research Laboratory, Summer School, Kotor, Yugoslavia.
1971-75 Research Fellow, NSF of the Republic of Serbia.
1976-77 Research Fellow, University of Maryland, College Park, (Fulbright Fellow with Dr Herbert Levitan).
1977-81 Lecturer, Department of Physiology, School of Biology, University of Belgrade, Yugoslavia.
1983-85 Assoc. Res. Scientist, Yale University School of Medicine, New Haven (with Dr Lawrence Cohen).
1981-93 Res. Scientist (joint appointment), Department of Cryobiology and Bioenergetics, Univ. Belgrade.
1982-88 Assistant Professor, Department of Physiology, School of Biology, University of Belgrade.
1989-93 Associate Professor, Department of Physiology, School of Biology, University of Belgrade.
1993-98 Associate Research Scientist, Yale University School of Medicine, New Haven, CT.
1999-2010 Research Scientist, Yale University School of Medicine, New Haven, CT.
2011-2023 Senior Research Scientist, Yale University School of Medicine, New Haven, CT.
Honors
Pre-doctoral Fellowship, Serbian National Science Foundation;
International Brain Research Laboratory fellowship, Kotor, Yugoslavia.
Fulbright Fellowship; University of Maryland – postdoctoral fellow;
MBL fellowship, Marine Biological Laboratory, Woods Hole, MA - postdoctoral fellowship.
C. Selected Peer-Review publications:
Antic S, Major G and Zecevic D (1999). Fast optical recording of membrane potential changes from dendrites of pyramidal neurons. J Neurophysiol. 82: 1615-1621. PMCID: PMC2037559
Canepari M, Djurisic M, Zecevic D (2007) Dendritic signals from rat hippocampal CA1 pyramidal neurons during coincident pre- and post-synaptic activity: a combined voltage- and calcium-imaging study. J Physiol. 580:463-8. PMCID: PMC2075540.
Djurisic M, Popovic M, Carnevale N, Zecevic D. (2008). Functional structure of the mitral cell dendritic tuft in the rat olfactory bulb. J Neurosci. 28:4057-68. PMID:18400905
Canepari M, Vogt K, Zecevic D (2008) Combining Voltage and Calcium Imaging from Neuronal Dendrites. Cell Mol. Neurobiol. 28(8):1079-93. PMCID:PMC3143714
Holthoff K, Zecevic D, Konnerth A (2010) Rapid time‐course of action potentials in spines and remote dendrites of mouse visual cortical neurons. J Physiol., 558:1085-1096. PMCID:PMC2852997
Canepari M, Willadt, S, Zecevic D and Kaspar EV (2010) Imaging Inhibitory Synaptic Potentials Using Voltage Sensitive Dyes. Biophysical J. 98: 2032-2040. PMCID:PMC2862202
Foust AJ, Popovic M, Zecevic D and McCormick DA (2010) Spike initiation and branch-point propagation fidelity elucidated in Purkinje neurons with voltage sensitive dye recording. J. Neurosci. 30: 6891-6902. PMCID:PMC2990270.
Canepari M, Popovic M, Vogt L, Holthoff K, Konnerth A, Salzberg B, Grinvald A, Antic S and Zecevic D (2010). Imaging Submillisecond Membrane Potential Changes from Individual Regions of Single Axons, Dendrites and Spines. In Membrane Potential Imaging in the Nervous System. Canepari M and Zecevic D (editors). Springer Neuroscience, New York.
Popovic MA, Foust AJ, McCormick DA, Zecevic D (2011). The spatio-temporal characteristics of action potential initiation in layer 5 pyramidal neurons: a voltage imaging study. J Physiol. 589:4167-87. PMCID:PMC3180577.
Foust AJ, Yu Y, Popovic M, Zecevic D, McCormick DA (2011). Somatic membrane potential and Kv1 channels control s
Research Interests
Papers共 80 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
bioRxiv (Cold Spring Harbor Laboratory) (2023)
BIOPHYSICAL JOURNALno. 22 (2023): 4303-4315
Encyclopedia of Computational Neurosciencepp.156-161, (2022)
Proceedings of SPIE (2019)
JOURNAL OF GENERAL PHYSIOLOGYno. 9 (2017): 16A-16A
Cited0Views0Bibtex
0
0
semanticscholar(2017)
Cited0Views0Bibtex
0
0
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn