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Research Statement
A significant technological challenge facing the biotechnology and biomedical industries is the integration of biological entities, such as proteins, DNA, or cells, into manufactured devices and, conversely, the engineering of materials to promote defined cellular functions in devices and in engineered tissues. Efforts to shrink the dimensions of bioanalytical systems as well as to incorporate cells and grow tissues on engineered scaffolds are generating tremendous demand for knowledge of the influence of interfacial properties on biological function and methods for improving the biological compatibility of materials.
In our research, we use surface physical chemical approaches to understand the biology-material interface and to engineer that interface by designing material composition and architecture. A variety of modern surface analytical and biochemical tools allow us to address biology-surface interactions on several length scales. With direct force measurements we quantify the molecular forces that control, for example, cell adhesion on engineered substrates. Similar investigations of biological recognition at interfaces revealed how the forces between cells or biomolecules and material surfaces affect biological function. Complementary studies of biosensor performance and cell adhesion in turn demonstrate how these molecular interactions impact whole cells and even device performance. These findings are generating design rules for affinity technologies that range from biosensors to protein purification.
A significant technological challenge facing the biotechnology and biomedical industries is the integration of biological entities, such as proteins, DNA, or cells, into manufactured devices and, conversely, the engineering of materials to promote defined cellular functions in devices and in engineered tissues. Efforts to shrink the dimensions of bioanalytical systems as well as to incorporate cells and grow tissues on engineered scaffolds are generating tremendous demand for knowledge of the influence of interfacial properties on biological function and methods for improving the biological compatibility of materials.
In our research, we use surface physical chemical approaches to understand the biology-material interface and to engineer that interface by designing material composition and architecture. A variety of modern surface analytical and biochemical tools allow us to address biology-surface interactions on several length scales. With direct force measurements we quantify the molecular forces that control, for example, cell adhesion on engineered substrates. Similar investigations of biological recognition at interfaces revealed how the forces between cells or biomolecules and material surfaces affect biological function. Complementary studies of biosensor performance and cell adhesion in turn demonstrate how these molecular interactions impact whole cells and even device performance. These findings are generating design rules for affinity technologies that range from biosensors to protein purification.
研究兴趣
论文共 369 篇作者统计合作学者相似作者
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期刊级别
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JOURNAL OF MOLECULAR CELL BIOLOGYno. 9 (2024)
BIOPHYSICAL JOURNALno. 4 (2024): 424-434
Biomacromoleculesno. 11 (2023): 5245-5254
CURRENT OPINION IN BIOMEDICAL ENGINEERING (2023): 100503-100503
biorxiv(2022)
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作者统计
#Papers: 371
#Citation: 13212
H-Index: 62
G-Index: 110
Sociability: 6
Diversity: 3
Activity: 47
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