基本信息
views: 0
Career Trajectory
Bio
Research Topic
Developmental genetics of organ formation; Drosophila
Research Topic: Organogenesis in a model system: Formation of the Drosophila salivary gland and trachea
Tube formation is a ubiquitous process required to sustain life in all multicellular organisms. Tubular organs in humans include the lungs, vasculature, digestive and excretory systems, as well as secretory organs such as the pancreas, salivary, prostrate, and mammary glands. My lab studies the Drosophila trachea and salivary gland as model systems for tube formation to learn how organ size, shape and function are normally controlled. Over the past several years, we have identified many genes expressed in the trachea and salivary gland, and are characterizing the subset required for early tube morphogenesis using a wide variety of genetic, imaging and biochemical approaches.
Among the genes we have characterized are two that encode transcription factors required for internalization of either the trachea or salivary gland, trachealess and fork head. Three other genes we have characterized encode transcription factors controlling tube elongation, ribbon, huckebein and hairy. Finally, several genes encode components of signaling pathways required for organ positioning. Current efforts in the lab are directed toward identifying and characterizing the morphogenetic roles of the downstream effector molecules regulated by these transcription factors and signaling pathways. We also study the mechanisms whereby the salivary gland becomes specialized for secretion and have learned that secretory capacity in this and other secretory organs is largely controlled by a single transcription factor, CrebA. Finally, we are beginning to leverage what we have learned about the Drosophila salivary gland to compromise mosquito salivary glands as one approach to limiting malarial transmission.
Developmental genetics of organ formation; Drosophila
Research Topic: Organogenesis in a model system: Formation of the Drosophila salivary gland and trachea
Tube formation is a ubiquitous process required to sustain life in all multicellular organisms. Tubular organs in humans include the lungs, vasculature, digestive and excretory systems, as well as secretory organs such as the pancreas, salivary, prostrate, and mammary glands. My lab studies the Drosophila trachea and salivary gland as model systems for tube formation to learn how organ size, shape and function are normally controlled. Over the past several years, we have identified many genes expressed in the trachea and salivary gland, and are characterizing the subset required for early tube morphogenesis using a wide variety of genetic, imaging and biochemical approaches.
Among the genes we have characterized are two that encode transcription factors required for internalization of either the trachea or salivary gland, trachealess and fork head. Three other genes we have characterized encode transcription factors controlling tube elongation, ribbon, huckebein and hairy. Finally, several genes encode components of signaling pathways required for organ positioning. Current efforts in the lab are directed toward identifying and characterizing the morphogenetic roles of the downstream effector molecules regulated by these transcription factors and signaling pathways. We also study the mechanisms whereby the salivary gland becomes specialized for secretion and have learned that secretory capacity in this and other secretory organs is largely controlled by a single transcription factor, CrebA. Finally, we are beginning to leverage what we have learned about the Drosophila salivary gland to compromise mosquito salivary glands as one approach to limiting malarial transmission.
Research Interests
Papers共 87 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Da Peng, Dorian Jackson, Bianca Palicha,Eric Kernfeld, Nathaniel Laughner, Ashleigh Shoemaker,Susan E. Celniker,Rajprasad Loganathan,Patrick Cahan,Deborah J. Andrew
DEVELOPMENTno. 2 (2024)
biorxiv(2024)
Nature Communicationsno. 1 (2022): 2949-2949
Geneticsno. 2 (2021)
Journal of Visualized Experiments (2021)
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn