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个人简介
After graduating with a degree in Chemistry from the University of Oxford, I undertook a research project in the Ecuadorian rainforest. This was followed by work in the USA on how genes function in normal and diseased states, using the fruit fly as an in vivo model system. I was involved in investigating early embryonic patterning events and then the regulation of neuronal survival.
During my doctoral degree at the University of Kent, I continued to work with the fly model and developed an interest in the control of cell growth and its significance for cancer cells. My findings showed that the homologue of the major human tumour suppressor gene PTEN acts as a brake on the oncogenic PI3-kinase pathway. The giant cells observed in PTEN mutant tissue highlighted cell growth control as a central feature of cancer biology.
In my postdoctoral years, I focused on the regulation of the microenvironmental sensor mTORC1, which is a downstream target of PI3-kinase/PTEN and acts to co-ordinate growth and metabolism. Collaborative work revealed that members of the Proton-assisted Amino acid Transporter (PAT or solute carrier SLC36) family acted as growth promoters via their ability to signal as ‘transceptors’ that can regulate mTORC1 activity.
During my doctoral degree at the University of Kent, I continued to work with the fly model and developed an interest in the control of cell growth and its significance for cancer cells. My findings showed that the homologue of the major human tumour suppressor gene PTEN acts as a brake on the oncogenic PI3-kinase pathway. The giant cells observed in PTEN mutant tissue highlighted cell growth control as a central feature of cancer biology.
In my postdoctoral years, I focused on the regulation of the microenvironmental sensor mTORC1, which is a downstream target of PI3-kinase/PTEN and acts to co-ordinate growth and metabolism. Collaborative work revealed that members of the Proton-assisted Amino acid Transporter (PAT or solute carrier SLC36) family acted as growth promoters via their ability to signal as ‘transceptors’ that can regulate mTORC1 activity.
研究兴趣
论文共 59 篇作者统计合作学者相似作者
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JOURNAL OF EXTRACELLULAR VESICLESno. 2 (2024)
JOURNAL OF EXTRACELLULAR VESICLESno. 2 (2024): e12416-e12416
Journal of extracellular vesiclesno. 2 (2024): e12404-e12404
JOURNAL OF EXTRACELLULAR VESICLESno. 2 (2024)
Adam Wells,Claudia C Mendes, Felix Castellanos, Phoebe Mountain, Tia Wright,S Mark Wainwright,M Irina Stefana,Adrian L Harris,Deborah C I Goberdhan,Clive Wilson
John D Mason, Ewan Marks,Shih-Jung Fan, Kristie McCormick,Clive Wilson,Adrian L Harris,Freddie C Hamdy,Chris Cunningham,Deborah C I Goberdhan
biorxiv(2023)
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PLoS geneticsno. 6 (2023): e1010815-e1010815
BRITISH JOURNAL OF CANCERno. 3 (2022): 471-473
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