基本信息
views: 137
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
My interest in the fundamental chemistry and biochemistry of vanadium and other transition metal ions is fueled by their applications as metals in medicine and their mechanisms of toxicity. The new compounds my group and I have synthesized include vanadium alkoxides, vanadium-aminoalcohol complexes, vanadium amino acid complexes, peroxovanadium complexes, hydroxylamidovanadium complexes, picolinate, dipicolinate and other related transition metal coordination complexes. We have been studying the fundamental coordination chemistry of vanadium and other transition metal compound in aqueous solution and other environments that can serve as model systems for what might occur in the varied environments of biological systems, which recently has focused on lipid or model lipid environments. Studies of lipid systems and microemulsion environments help us understand how drugs and metabolites interact and penetrate lipid interfaces. Indeed, we often need the solid state structural characterization of both known and our novel compounds as benchmark data for our solution and biological studies.
The labile nature of many vanadium(V) systems has resulted in our careful solution characterizations of structure, stability and lability. Our solution studies are carried out using spectroscopic methods: mainly 1D and non-routine 2D NMR spectroscopies, however, EPR, UV-vis, IR spectroscopy and recently magnetic methods are all used in our work. Our biochemical studies with vanadium can be viewed as studies in the area of trace metal metabolism since we have studied the effects of vanadium compounds on biological systems ranging from the isolated proteins to cell culture to plants to animals. Our interest in vanadium metabolism has expanded to include phosphorus metabolism as well as analytical methods needed for measurements of metabolites. Vanadium(V) can act as a metal ion or as a ground state and/or transition state phosphate analogs and have served as an excellent model in many studies, but we do not limit ourselves to vanadium. Enzyme types of particular interest include phosphatases, kinases and beta polymerase. We also study the interactions of lipids with metal ions in confined spaces and recently have become interested in methods of drug formulation.
The labile nature of many vanadium(V) systems has resulted in our careful solution characterizations of structure, stability and lability. Our solution studies are carried out using spectroscopic methods: mainly 1D and non-routine 2D NMR spectroscopies, however, EPR, UV-vis, IR spectroscopy and recently magnetic methods are all used in our work. Our biochemical studies with vanadium can be viewed as studies in the area of trace metal metabolism since we have studied the effects of vanadium compounds on biological systems ranging from the isolated proteins to cell culture to plants to animals. Our interest in vanadium metabolism has expanded to include phosphorus metabolism as well as analytical methods needed for measurements of metabolites. Vanadium(V) can act as a metal ion or as a ground state and/or transition state phosphate analogs and have served as an excellent model in many studies, but we do not limit ourselves to vanadium. Enzyme types of particular interest include phosphatases, kinases and beta polymerase. We also study the interactions of lipids with metal ions in confined spaces and recently have become interested in methods of drug formulation.
Research Interests
Papers共 599 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Journal of inorganic biochemistry (2024): 112610-112610
Pharmaceuticals (Basel, Switzerland)no. 6 (2024): 760
ANTIOXIDANTSno. 3 (2024)
Journal of inorganic biochemistry (2024): 112637-112637
Journal of Inorganic Biochemistrypp.112610, (2024)
Allison A. Haase, Skyler A. Markham,Heide Murakami, John Hagan, Kate Kostenkova,Jordan E Koehn,Canan Uslan, Cheryl N. Beuning, Lee Brandenburg,Joseph Zadrozny,Aviva Levina,Debbie C. Crans,
New Journal of Chemistry (2024)
Jiaqi Guo,Jun Wang,Pei Liang,E. Tian,Dan Liu,Zhaoqi Guo,Jingyu Chen,Yuejin Zhang, Zhanghong Zhou,Weijia Kong,Debbie C. Crans,Yisheng Lu,
Coordination Chemistry Reviews (2024): 215791
British journal of pharmacology (2024)
Frontiers in Chemical Biology (2024)
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn