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My research aims to develop novel strategies to modulate vessel growth. This is directly relevant to the ischemic heart, where neovascular growth is insufficient and current strategies to improve this have failed.
I have worked on different aspects of gene regulation throughout my career. In particular, my research focuses on the transcriptional pathways which regulate the dynamic gene expression patterns required for correct formation and function of the mammalian vascular system. During my post-doctoral research, I combined the analysis of gene enhancers (densely clustered groups of transcription factor binding motifs which regulate spatial and temporal patterns of gene transcription) with in vivo gene depletion models to describe a transcriptional pathway that regulates endothelial cell (EC) specification (De Val et al., Cell, 2008). As an independent researcher, my lab is focused on understanding the regulatory mechanisms controlling angiogenesis (new EC growth from existing vessels), vascular differentiation and heterogeneity.
I have worked on different aspects of gene regulation throughout my career. In particular, my research focuses on the transcriptional pathways which regulate the dynamic gene expression patterns required for correct formation and function of the mammalian vascular system. During my post-doctoral research, I combined the analysis of gene enhancers (densely clustered groups of transcription factor binding motifs which regulate spatial and temporal patterns of gene transcription) with in vivo gene depletion models to describe a transcriptional pathway that regulates endothelial cell (EC) specification (De Val et al., Cell, 2008). As an independent researcher, my lab is focused on understanding the regulatory mechanisms controlling angiogenesis (new EC growth from existing vessels), vascular differentiation and heterogeneity.
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crossref(2024)
Nature Cardiovascular Researchno. 7 (2024): 785-798
crossref(2023)
CURRENT OPINION IN PHYSIOLOGY (2023): 100691-100691
ELIFE (2023)
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GENES & DEVELOPMENTno. 19-20 (2022): 1096-1096
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