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Research in the de Lange lab focuses on human and mouse telomeres, which are made up of long arrays of double-stranded TTAGGG repeats that end in a single-stranded 3′ overhang. The lab identified a six-subunit protein complex, which they named shelterin, that specifically binds to telomeres. Using genetic approaches, de Lange and her colleagues determined the fate of telomeres lacking one or more of the six shelterin subunits. The results showed that cells lacking shelterin perceive their natural chromosome ends as sites of DNA damage, leading to DNA damage signaling and inappropriate repair.
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Science (New York, N.Y.)no. 6684 (2024): 763-770
Ceylan Sonmez, Beatrice Toia, Patrik Eickhoff, Andreea Medeea Matei, Michael El Beyrouthy,Bjoern Wallner,Max E. Douglas,Titia de Lange,Francisca Lottersberger
NUCLEIC ACIDS RESEARCH (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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GENES & DEVELOPMENTno. 13-14 (2023): 555-569
bioRxiv : the preprint server for biology (2023)
Zi-Ning Choo,Julie M Behr,Aditya Deshpande,Kevin Hadi, Xiaotong Yao,Huasong Tian,Kaori Takai, George Zakusilo,Joel Rosiene,Arnaud Da Cruz Paula,Britta Weigelt,Jeremy Setton,
Nature geneticsno. 12 (2023): 2139-+
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