基本信息
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RESEARCH SUMMARY
Dr. Roberts investigates the role of extracellular matrix components in the tumor microenvironment in regulating tumor angiogenesis and antitumor immunity. His group discovered that thrombospondin-1 signaling through its receptor CD47 controls vascular cell responses to ischemic stress by enhancing nitric oxide/cGMP signaling and cellular responses to genotoxic stress by induction of protective autophagy, induction of anabolic metabolism, and enhanced DNA repair. CD47 also regulates stem cell self-renewal by controlling c-Myc. His lab developed novel therapeutics targeting CD47 that improve survival of ischemic injuries and increase resistance of nonmalignant cells and tissues to genotoxic stress caused by chemotherapy and ionizing radiation. The same agents enhance ablation of tumors by radio- and chemotherapy by activating CD8 T cell and NK cell cytotoxic activities.
Areas of Expertise
1) extracellular matrix, 2) stress responses, 3) stem cell reprogramming, 4) angiogenesis, 5) tumor immunology, 6) autophagy
Research Interests
Papers共 616 篇Author StatisticsCo-AuthorSimilar Experts
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Sukhbir Kaur, Bianca Reginauld,Sam Razjooyan, Trung Phi,Satya P Singh, Thomas J Meyer,Margaret C Cam,David D Roberts
bioRxiv : the preprint server for biology (2024)
Sukhbir Kaur, Bianca Reginauld,Sam Razjooyan, Trung Phi,Satya P. Singh, Thomas J. Meyer,Margaret C. Cam,David D. Roberts
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2024)
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGYno. Pt B (2024): 22-31
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
crossref(2023)
Sukhbir Kaur, Duha Awad,Richard P. Finney, Thomas J. Meyer,Satya P. Singh,Margaret C. Cam,Baktiar O. Karim,Andrew C. Warner,David D. Roberts
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