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Hair cells of the inner transduce mechanical stimui to electrical signals transmitted to the brain. Hair cells of the auditory organs respond to sound stimuli for hearing perception; those in the vestibular organs respond to gravity and head movements for perception of balance. Hair cells are so named because they have actin-rich protrusions, stereocilia, at their apical end. Displacement of stereocilia opens ion channels resulting in depolarization and release of transmitter from synapses at the basal end of the cell to terminals of innervating afferent nerves. Damage and loss of hair cells are leading causes of hearing and balance disorders, which affect over 40 million people in the US. Hair cells are susceptible to environmental insults, including noise, chemical exposure and accumulated damage during aging. Genetic disorders are common, affecting more than 1:500 children. Hair cell loss in humans is irreversible.
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Ethan Bustad, Emma Mudrock, Elizabeth M Nilles,Andrea Mcquate, Monica Bergado, Alden Gu, Louie Galitan, Natalie Gleason,Henry C Ou,David W Raible, Rafael E Hernandez,Shuyi Ma
Frontiers in pharmacology (2024): 1363545-1363545
Gareth T Powell, Ana Faro,Yuguang Zhao, Heather Stickney,Laura Novellasdemunt,Pedro Henriques,Gaia Gestri, Esther Redhouse White,Jingshan Ren,Weixian Lu,Rodrigo M Young,Thomas A Hawkins,
Science (New York, N.Y.)no. 6695 (2024): 573-579
Frontiers in Molecular Neuroscience (2023): 1274822
CELLno. 23 (2023): 5015-+
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