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David Harrison
教授
Department of Pharmacology
School of Medicine, Vanderbilt University;Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University;Division of Clinical Pharmacology, Vanderbilt University Medical Center;Department of Medicine, Vanderbilt University Medical Center
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基本信息
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个人简介
His research laboratory has been focused on understanding how inflammation, and in particular, the adaptive immune response contributes to hypertension. Several years ago, they found that T cells are essential for the development of hypertension. His lab has shown that various hypertensive stimuli, including angiotensin II, norepinephrine and DOCA-salt cause activation of T cells and leads to their accumulation in the perivascular fat and kidneys. The data indicates that T cell-derived cytokines such as IL-17 and TNF-a enhance vasoconstriction and sodium retention, leading to the hypertensive phenotype. Central signals derived from the circumventricular organs contribute to T cell activation, and manipulation of signals from this region affect T cell activation and the eventual elevation in blood pressure caused by angiotensin II.
研究兴趣
论文共 740 篇作者统计合作学者相似作者
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Hypertension (Dallas, Tex. : 1979)no. 5 (2024): e44-e46
Circulation researchno. 1 (2024): 30-32
Circulation researchno. 10 (2024): 1276-1291
Physiological reportsno. 13 (2024): e16127-e16127
D. G. Harrison, M. Bader, L. O. Lerman, G. Fink, S. A. Karumanchi, J. F. Reckelhoff, M. L. S. Sequeira-Lopez, R. M. Touyz
Hypertension (Dallas, Tex. : 1979)no. 1 (2024): 3-5
Laventa M Obare,Joshua Simmons,Jared Oakes,Xiuqi Zhang, Cindy Nochowicz,Stephen Priest,Samuel S Bailin,Christopher M Warren,Mona Mashayekhi,Heather K Beasley,Jianqiang Shao,Leslie M Meenderink,
bioRxiv : the preprint server for biology (2024)
Nutrition, metabolism, and cardiovascular diseases : NMCDno. 7 (2023): 1398-1406
Celestine N. Wanjalla, J. Aaron Simmons,Jared Oakes,Xiuqi Zhang, Cindy Nochowivz,Stephen Priest,Samuel Bailin, Christopher M Watten,Mona Mashayekhi,Heather K. Beasley,Jian Wang,Leslie M. Meenderink,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Gwenyth J. Joseph,Lawrence A. Vecchi,David Kell,Sasidhar Uppuganti,Margaret Durdan, Wei Chen,David Harrison,Jeffry S. Nyman,Megan Weivoda,Rachelle W. Johnson
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 53-53
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