基本信息
浏览量:183
职业迁徙
个人简介
Research: The central theme of the laboratory is the potential relationship of intracellular pro-proliferative / pro-survival factors and how tumor cells respond to therapeutic modalities. His group hypothesize that specific pro-survival pathways, both alone and more likely in combination, and their upstream signaling factors are potential molecular targets to improve the cytotoxic effects of anti-cancer agents including but not limited to ionizing radiation. These challenges have led his laboratory to concentrate its efforts into the role that longevity genes might play a role in carcinogenesis. The overarching theme of this aspect of the laboratory is based on one of the fundamental observations in Oncology. That is: cancer is a disease of aging, and the rate of malignancies increases significantly as a function of age. To address this idea the group constructed mice seven years ago that have the mitochondrial (Sirt3) and cytoplasmic (Sirt2) sirtuin genes deleted. In the past four years the group have shown that Sirt3 is genomically expressed, mitochondrial localized tumor suppressor (Hyun et al., 2010, Cancer Cell) and suggest a relationship that connects protein acetylation, mitochondrial metabolism, and proteins that detoxify cellular reactive oxygen species (Tao et al., 2010, Mol. Cell). Finally, the group has also recently shown that Sirt2 is also a TS gene that connects aging, mitotic cell cycle regulation, and carcinogenesis (Kim et al., 2011, Cancer Cell). This work is currently funded by two NCI R01s, and a DOD idea award.
研究兴趣
论文共 210 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
David Gius, Margo C. Funk,Eric Y. Chuang,Sheng Feng,Phyllis C. Huettner,Loan Nguyen, C. Matthew Bradbury,Mark Mishra, Shuping Gao,Barbara M. Buttin,David E. Cohn,Matthew A. Powell,
crossref(2023)
crossref(2023)
Lunching Sun, Lei Huang,Phuongmai Nguyen,Kheem S. Bisht,Gil Bar-Sela,Allen S. Ho, C. Matthew Bradbury,Wenqiang Yu,Hengmi Cui,Sunmin Lee,Jane B. Trepel,Andrew P. Feinberg,
crossref(2023)
crossref(2023)
crossref(2023)
crossref(2023)
Phuongmai Nguyen,Hengmi Cui,Kheem S. Bisht, Lunching Sun,Krish Patel,Richard S. Lee,Hiroyuki Kugoh, Mitsuo Oshimura,Andrew P. Feinberg,David Gius
crossref(2023)
PHYSIOLOGYno. S1 (2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn