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One major research focus has been the impact of vaccination and nutritional status on immune responses and infectious disease resistance in a highly relevant guinea pig model of low-dose pulmonary tuberculosis (TB). Protein-deprived guinea pigs exhibit many of the metabolic and clinical hallmarks of kwashiorkor in humans. In many papers published over the past 35 years, with continual funding from NIH, we have dissected the detrimental impact of diet on mechanisms of vaccine-induced resistance of guinea pigs to pulmonary TB.
In order to study macrophage-lymphocyte interactions, including cytokine cross-talk, in the guinea pig model of TB, we have sub-cloned and expressed several guinea pig cytokine and chemokine genes, and studied the immunological response to vaccination and virulent mycobacterial infection in various leukocyte populations ex vivo, and directly in pulmonary granulomas in situ. In addition, the development of both prokaryotic and eukaryotic expression systems have allowed us to produce sufficient quantities of recombinant protein to alter cellular functions in vivo and in vitro, and to raise neutralizing antibodies to block cytokine function in cell cultures and in the whole animal.
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crossref(2023)
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Frontiers research topics (2020)
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Reference Module in Biomedical Sciences (2017)
David N. McMurray, Álvaro Echeverry Perea
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