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Professor David Sansom
Professor of Transplant Immunology
About
Research in the Sansom lab focusses on fundamental aspects of how immune checkpoints influence T cell activation decisions.
Research summary
The activation of T cells is a critical part of the immune response. Without effective T cell responses we could not fight infections properly and vaccines would not work. However, T cell responses can also be dangerous to our bodies and it is clear that diseases such as rheumatoid arthritis and type-I diabetes as well as rejection of transplanted organs all involve unwanted T cell responses.
My laboratory works on fundamental aspects of how T cells determine whether to make immune responses or not. In particular we focus on the interplay between two receptors on T cells, CD28 and CTLA-4 and their binding partners, CD80 and CD86. Our work on the underlying molecular and cellular mechanisms has led to advances in understanding how the CD28/CTLA-4 system functions and this knowledge has been used to develop tests of human T cell function and regulatory T cell suppression.
Professor of Transplant Immunology
About
Research in the Sansom lab focusses on fundamental aspects of how immune checkpoints influence T cell activation decisions.
Research summary
The activation of T cells is a critical part of the immune response. Without effective T cell responses we could not fight infections properly and vaccines would not work. However, T cell responses can also be dangerous to our bodies and it is clear that diseases such as rheumatoid arthritis and type-I diabetes as well as rejection of transplanted organs all involve unwanted T cell responses.
My laboratory works on fundamental aspects of how T cells determine whether to make immune responses or not. In particular we focus on the interplay between two receptors on T cells, CD28 and CTLA-4 and their binding partners, CD80 and CD86. Our work on the underlying molecular and cellular mechanisms has led to advances in understanding how the CD28/CTLA-4 system functions and this knowledge has been used to develop tests of human T cell function and regulatory T cell suppression.
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论文共 142 篇作者统计合作学者相似作者
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Christina JF Courreges, Elizabeth CM Davenport,Benoit Bilanges, Elena Rebollo-Gomez,Jens Hukelmann, Priya Schoenfelder,James R Edgar,David Sansom,Cheryl Scudamore,Rahul Roychoudhuri,Oliver A Garden,Bart Vanhaesebroeck,
biorxiv(2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 31 (2023): e2300895120-e2300895120
bioRxiv : the preprint server for biology (2023)
Alan Kennedy, Maximillian Robinson,Claudia Hinze,Erin Waters,Cayman Williams,Neil Halliday,Simon Dovedi,David Sansom
biorxiv(2022)
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