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个人简介
David M. Sabatini’s laboratory studies the mechanisms that regulate physiological and pathological growth and metabolism in mammals. His lab has focused significant efforts on the mTOR pathway. This signaling network, the target of the well-known drug rapamycin, is a central regulator of growth and aging and is dysregulated in common diseases, including cancer. The laboratory identified many of the core components of the pathway, including the mTORcontaining complexes mTORC1 and mTORC2, as well as the machinery through which mTORC1 senses amino acids to promote anabolism. This latter work led to the discovery of the direct sensors for leucine and arginine and identified the lysosome as a signaling organelle. Sabatini’s laboratory has also studied how feeding and fasting regulate tissue physiology, including hepatic ketogenesis, intestinal stem cell self-renewal, and tumor growth. A part of the laboratory focuses on how central small molecule metabolism affects growth control and has investigated the role of the serine synthesis pathway in cancer and used genetic screens to define essential functions for mitochondria in cell proliferation. Lastly, the laboratory has been active in technology development, and has created methods for purifying unstable protein complexes, cell-based microarrays for high throughput screening of cDNAs, and genome-scale RNAi and CRISPR/Cas9 libraries that are widely used.
研究兴趣
论文共 407 篇作者统计合作学者相似作者
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Hans-Georg Sprenger, Melanie J. Mittenbuehler,Yizhi Sun,Jonathan G. Van Vranken, Sebastian Schindler,Abhilash Jayaraj,Sumeet A. Khetarpal, Ariana Vargas-Castillo,Anna M. Puszynska, Jessica B. Spinelli,Andrea Armani,Tenzin Kunchok,
crossref(2024)
Yong Yu,Shihong M. Gao, Youchen Guan,Pei-Wen Hu,Qinghao Zhang, Jiaming Liu, Bentian Jing,Qian Zhao,David M. Sabatini,Monther Abu-Remaileh,Sung Yun Jung,Meng C. Wang
ELIFE (2024)
Qingsong Liu,Chunxiao Xu,Sivapriya Kirubakaran,Xin Zhang, Wooyoung Hur,Yan Liu, Nicholas P. Kwiatkowski,Jinhua Wang,Kenneth D. Westover,Peng Gao,Dalia Ercan,Mario Niepel,
crossref(2023)
Brian C. Grabiner,Valentina Nardi,Kıvanç Birsoy,Richard Possemato,Kuang Shen, Sumi Sinha, Alexander Jordan,Andrew H. Beck,David M. Sabatini
crossref(2023)
bioRxiv : the preprint server for biology (2023)
Natasha L. Curry,Mari Mino-Kenudson,Trudy G. Oliver,Ömer H. Yilmaz, Vedat O. Yilmaz,Jade Y. Moon,Tyler Jacks,David M. Sabatini,Nada Y. Kalaany
crossref(2023)
Brian C. Grabiner,Valentina Nardi,Kıvanç Birsoy,Richard Possemato,Kuang Shen, Sumi Sinha, Alexander Jordan,Andrew H. Beck,David M. Sabatini
crossref(2023)
crossref(2023)
Qingsong Liu,Chunxiao Xu,Sivapriya Kirubakaran,Xin Zhang, Wooyoung Hur,Yan Liu, Nicholas P. Kwiatkowski,Jinhua Wang,Kenneth D. Westover,Peng Gao,Dalia Ercan,Mario Niepel,
crossref(2023)
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