基本信息
浏览量:315
职业迁徙
个人简介
A long-standing interest is to understand the cellular and molecular basis for this vulnerability of the human neonate to infection with intracellular pathogens that require T helper 1 (Th1) cells [CD4 T cell producing interferon-gamma (IFN-gamma)] for effective immune control. We have previously shown that CD4 T cells of the newborn have a unique limitation in the ability to produce certain effector molecules, such as CD40-ligand (CD154) and IFN-gamma compared to these cells in adults due to both reduced gene transcriptional and impaired signals that lead to gene transcription. Recently, we have shown that these limitations apply to physiological T-cell activation, e.g., using allogeneic dendritic cells. Defining the molecular mechanisms for decreased IFN-gamma production by neonatal CD4 T cells is a current focus.
研究兴趣
论文共 148 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Jing Guo,Roshni Roy Chowdhury,Vamsee Mallajosyula,Jianming Xie,Megha Dubey,Yuanyuan Liu,Jing Li,Yu-Ling Wei,Brad A Palanski, Conghua Wang, Lingfeng Qiu, Mané Ohanyan,
Proceedings of the National Academy of Sciences of the United States of Americano. 4 (2024): e2315592121-e2315592121
Yael Gernez, Bindu Sathi,Juanita Valdes Camacho, Latha Rao, Berthil Glader,Deepika Singh, Elisabeth Hoyte,David Lewis,Maria Grazia Roncarolo, May Chien,Rosa Bacchetta,Katja Weinacht
Journal of Allergy and Clinical Immunologyno. 2 (2024): AB186
Jing Guo,Roshni Roy Chowdhury,Vamsee Mallajosyula,Jianming Xie,Megha Dubey, Yuanyuan Liu,Jing Li,Yu-ling Wei,Brad A. Palanski, Conghua Wang, Lingfeng Qiu, Mane Ohanyan,
Hayley A. Gans,David B. Lewis
Principles and Practice of Pediatric Infectious Diseasepp.106-113.e2, (2023)
PEDIATRIC BLOOD & CANCER (2023): S75-S76
引用0浏览0引用
0
0
JOURNAL OF CLINICAL ONCOLOGYno. 16 (2023): 7514-7514
引用0浏览0引用
0
0
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn