基本信息
浏览量:53
职业迁徙
个人简介
Major Areas of Research
Study of parasite and sand fly molecules controlling the development of transmissible infections in the vector
Development of vaccines against leishmaniasis and their evaluation using infected sand fly challenge
Mechanisms of acquired resistance in cutaneous leishmaniasis and those controlling persistent infection
Mechanisms underlying pathogenesis and immunosuppression in human visceral leishmaniasis and development of host-directed therapies
Study of sexual reproductive strategies in Leishmania and the development of forward genetic approaches to identify virulence genes
Program Description
Research in the Intracellular Parasite Biology Section (IPBS) focuses on the immunology and cell biology of leishmanial infections and the biology of Leishmania parasites within their mammalian hosts and sand-fly vectors. The research may have relevance to diseases, such as tuberculosis, caused by other intracellular pathogens or to other vector-borne diseases, such as malaria.
The IPBS is composed of an interdisciplinary group of immunologists, cell biologists, entomologists, and computational biologists conducting basic and translational research aimed at the following:
Understanding molecular interactions at the sand fly-Leishmania interface that control the development of transmissible infections, including the role of insect microbiota
Exploiting a recently identified sexual cycle of Leishmania during their development in the sand fly vector to investigate sexual recombination as a key reproductive strategy to generate diversity, and to identify genes controlling important traits, such as virulence, tissue tropism, and drug resistance
Understanding the role of myeloid subsets in the skin development of severe cutaneous pathology due to L. major
Understanding the mechanisms underlying the immunologic defects in patients with visceral leishmaniasis in India, focusing on the role of IL-10 and its inhibition as an approach to therapy
Identifying the important human infection reservoirs for transmission of visceral leishmaniasis in India
研究兴趣
论文共 275 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Nature communicationsno. 1 (2023): 7159-14
Nature communicationsno. 1 (2023): 1-15
International Journal of Infectious Diseases (2023): S23-S23
引用0浏览0引用
0
0
Research square (2023)
Research Square (Research Square) (2023)
Gabriela Pessenda,Andrea Paun, Tiago Rodrigues Ferreira,Eduardo Pinheiro Amaral,Juraj Kabat,Olena Kamenyeva,Sundar Ganesan,Sang Hun Lee,David Lawrence Sacks
Journal of Immunologyno. 1 (2023): 71.03-71.03
引用1浏览0WOS引用
1
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn