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个人简介
How do some neurons survive a lifetime while others succumb to neurodegeneration? Answering this fundamental question will be critical for treating and preventing neurodegenerative diseases. Yet to answer it we first need to understand what governs neuronal survival and how cellular stresses interfere with survival mechanisms. To do this, we study the molecular pathways that promote neuronal survival with a particular focus on the survival of axons. We use a range of molecular, genetic, biochemical, and imaging techniques to define pathways that suppress cell death and maintain metabolic support. We then ask how stresses—including misfolded proteins, physical injury, and inflammation—disrupt these survival pathways to promote neurodegeneration. Our ultimate goal is to define how a neuron reacts to its environment and how environmental stimuli affect the balance between survival and death. This approach will allow us to understand how neurodegeneration occurs and to identify novel therapeutic targets.
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medRxiv (Cold Spring Harbor Laboratory) (2024)
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesityno. 1 (2024): 1-8
Michael J Binks,Amy S Bleakley,Susan J Pizzutto, Michelle Lamberth, Verity Powell,Jane Nelson,Adrienne Kirby,Peter S Morris,David Simon,E Kim Mulholland,Geetha Rathnayake,Amanda J Leach,
medrxiv(2023)
Brain sciencesno. 7 (2023): 1043-1043
David K. Simon, Nuno Mendonca,Joerg Holenz, Jennifer Liu,Guillermo Castilla-Fernandez,Miguel M. Fonseca
MOVEMENT DISORDERS (2023): S10-S11
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Xv-Shen Ding, Li Gao,Zheng Han,Simona Eleuteri,Wei Shi, Yun Shen, Zi-Yao Song,Mingming Su, Qian Yang,Yan Qu,David K Simon,Xue-Lian Wang,
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D-Core
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