The overall goal of my research is to develop more accurate radiobiological dose-response models that will advance biologically-guided radiation therapy (BGRT) for cancer patients. I hope to make scientific contributions to improve our basic understanding of the underlying physical and biological mechanisms that govern radiation response. In my recent research, I have investigated the effects of the spatial pattern of energy deposition on the relative biological effectiveness of x-rays, protons, and carbon ions for various biological endpoints. I have examined the combined effects of cellular oxygen concentration and spatial energy deposition on DNA damage induction and processing and cell death. I have a broad background in radiation physics and radiation biology.