RESEARCH INTERESTS Structure and Function of Anti-Retroviral Host Proteins I am interested in how HIV and other retroviruses interact with components of the host cell during infection. These interactions govern both the ability of the virus to reproduce, and the ability of the cell to block and contain infection. Of particular interest are members of the TRIM protein family that can recognise retroviral components within the cell and then act to block the viral lifecycle, disrupting infection. We aim to characterise these proteins and the interactions they make using X-ray crystallography, small-angle X-ray scattering and other biophysical techniques. How to metal based chemotherapeutics target proteins? Platinum compounds form the foundation of many treatment regimens for cancer. However, these compounds are promiscuous lacking the specificity of other chemotherapeutic compounds. This results in off target and side-effects that limit their usability in treatment. We are interested in how metal-based compounds interact with proteins, and understanding how we can generate specificity to improve treatment options for cancer patients.