His responsibilities at Penn State have included patient care in the areas of hematological malignancies and leukemia treatments, blood and marrow transplantation, teaching, research, and administration.

Currently, Dr. Claxton is actively involved in patient care of patients with blood malignancies. His clinical focus is on leukemia s and myelodysplastic syndrome and bone marrow transplantation. He teaches medical students, residents, and sub-specialty fellows. He has numerous publications in the field of leukemia molecular biology and therapeutics. He has active clinical research interests in leukemia therapeutics and is also active in translational and bench research and leukemia therapeutics.