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The phenotype of a mammalian cell is modulated in response to physiological signals partly through the differential activation of specific gene expression. One way cells detect environmental cues and cell-cell interactions is through binding of extracellular ligands to cell-surface receptors. Responses to cell surface binding of cytokines, a diverse family of secreted polypeptides regulating cellular growth and differentiation, lead to profound alterations in the functions and metabolic profile of susceptible cells. We focus on the mechanisms of action of growth inhibitory growth stimulatory interferons (IFNs) and inflammatory cytokines.The immediate response to IFNs and many inflammatory cytokines is mediated by transcriptional activation of discrete sets of stimulated genes through the action of transcription factors of the STAT family.
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Mitochondrial Communications (2024): 1-13
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Karni Schlessinger,David E. Levy
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Karni Schlessinger,David E. Levy
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Karni Schlessinger,David E. Levy
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