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David Moore has made seminal discoveries in the roles of nuclear hormone receptors in health and disease. The 48 family members of this superfamily include the steroid receptors and a larger number of proteins termed orphan receptors whose functions and cognate hormones were initially not known. The Moore laboratory's efforts in this field started with the discovery of several orphan family members, including CAR and SHP. He has also contributed to the identification of new ligands and signaling mechanisms, including the discovery of a new class of ligands termed inverse agonists that do not depend on agonist displacement for their inhibitory effects on agonist-independent receptors. More recently, he has focused on the physiologic functions and disease relevance of several orphans and former orphans that act in the liver, including CAR and the bile acid receptor FXR. Following the leads that these and other receptors have provided, he has driven our current understanding of them as key metabolic regulators that maintain healthy homeostasis when they function appropriately, but can drive pathologic responses when dysregulated.
研究兴趣
论文共 660 篇作者统计合作学者相似作者
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Sung Ho Lee, Ji Ho Suh, Mi Jeong Heo,Jong Min Choi,Yang Yang, Hyun-Jung Jung,Zhanguo Gao,Yongmei Yu,Sung Yun Jung,Mikhail G Kolonin,Aaron R Cox,Sean M Hartig,
Diabetesno. 5 (2024): 701-712
Journal of Immunologyno. 1 (2023): 61.14-61.14
Matias G. De Vas, Fanny Boulet, Shweta S. Joshi,Myles G. Garstang,Tahir N. Khan,Goutham Atla,David Parry,David Moore,Ines Cebola,Shuchen Zhang,Wei Cui,Anne K. Lampe,
Molecular metabolism (2023): 101717-101717
HEPATOLOGY (2023): S210-S211
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Jennifer Padilla, Noha M Osman,Beatrice Bissig-Choisat,Sandra L Grimm,Xuan Qin,Angela M Major,Li Yang,Dolores Lopez-Terrada,Cristian Coarfa,Feng Li,Karl-Dimiter Bissig,David D Moore,
Journal of hepatologyno. 2 (2023): 282-292
Military medicine (2023)
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